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P51559 Sigma-Aldrich

Propionyl chloride

98%

  • CAS Number 79-03-8

  • Linear Formula CH3CH2COCl

  • Molecular Weight 92.52

  •  Beilstein/REAXYS Number 385632

  •  EC Number 201-170-0

  •  MDL number MFCD00000745

  •  PubChem Substance ID 24898602

  •  NACRES NA.22

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Properties

Related Categories Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks More...
Quality Level   200
vapor density   3.2 (vs air)
assay   98%
refractive index   n20/D 1.404 (lit.)
bp   77-79 °C (lit.)
mp   −94 °C
density   1.059 g/mL at 25 °C (lit.)
SMILES string   CCC(Cl)=O
InChI   1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3
InChI key   RZWZRACFZGVKFM-UHFFFAOYSA-N

Description

Application

Propionyl chloride can be used as an acylating agent:
• To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.

It can also be used:
• For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
• In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.

Packaging

25, 500 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
EUH014
RIDADR 
UN 1815 8(3) / PGII
WGK Germany 
WGK 1
Flash Point(F) 
42.8 °F - closed cup
Flash Point(C) 
6 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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