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QBD10009 Sigma-Aldrich

Biotin-dPEG®4-TFP ester

  • Empirical Formula (Hill Notation) C27H37F4N3O8S

  • Molecular Weight 639.66

  •  PubChem Substance ID 329823873

  •  NACRES NA.22

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Properties

Related Categories Biotins, Chemical Biology, Chemical Synthesis, PEGylation, dPEGs from Quanta Biodesign More...
assay   >90%
form   solid or viscous liquid
reaction suitability   reaction type: Biotinylations
reactivity: amine reactive
  reagent type: cross-linking reagent
polymer architecture   shape : linear
functionality : monofunctional
shipped in   ambient
storage temp.   −20°C
SMILES string   O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O

Description

Features and Benefits

Biotin-dPEG®4-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyzes more slowly than NHS ester in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®4-TFP ester has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. The PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Polyethylene Glycol (PEG) Selection Guide

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are synthesized using a ring-opening polymerization of et...
Keywords: Adhesion, Bacterial conjugations, Click chemistry, Molecular biology, PEGylations, Polymerization reactions, Ring-opening polymerization

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