EMAIL THIS PAGE TO A FRIEND
T76201 Sigma-Aldrich

Trimethylene oxide

97%

Synonym: 1,3-Epoxypropane, 1,3-Propylene oxide, Cyclooxabutane, Oxacyclobutane, Oxetane

  • CAS Number 503-30-0

  • Empirical Formula (Hill Notation) C3H6O

  • Molecular Weight 58.08

  •  Beilstein/REAXYS Number 102382

  •  EC Number 207-964-3

  •  MDL number MFCD00005167

  •  PubChem Substance ID 24900463

  •  NACRES NA.22

Purchase

Properties

Related Categories Asymmetric Synthesis, Building Blocks, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks,
Quality Level   200
vapor pressure   5.09 psi ( 20 °C)
assay   97%
refractive index   n20/D 1.388-1.396
  n20/D 1.392 (lit.)
bp   50 °C (lit.)
density   0.893 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   C1COC1
InChI   1S/C3H6O/c1-2-4-3-1/h1-3H2
InChI key   AHHWIHXENZJRFG-UHFFFAOYSA-N

Description

Application

• Trimethylene oxide is a strained cyclic ether which can be used to replace carbonyl / gem-dimethyl groups during molecular modelling of bioactive molecules.
• It can be incorporated in various bioactive molecule and drug substances for its improved physicochemical properties, via novel C-H activation methods.
• Trimethylene oxide can also be used in the synthesis of poly(trimethylene oxide) and related polymer electrolytes.

Packaging

5, 10 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993BF 3 / PGII
WGK Germany 
1
RTECS 
RQ6825000
Flash Point(F) 
-4 °F
Flash Point(C) 
-20 °C

Meet Synthia - Retrosynthesis Sofware
Protocols & Articles

Articles

Oxetanes

Oxetanes are the closest homologs to epoxides, but historically have received far less attention than their three-membered ringed brethren. However, oxetanes have received increasing exposure as attr...
Mark Redlich
Chemfiles Volume 10 Article 4
Keywords: Antibiotics, Building blocks, Drug discovery, Medicinal chemistry

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?