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W294705 Sigma-Aldrich

Propyl gallate

≥98%, FCC

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

  • CAS Number 121-79-9

  • Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3

  • Molecular Weight 212.20

  •  FEMA Number 2947

  •  Beilstein/REAXYS Number 1877976

  •  EC Number 204-498-2

  •  MDL number MFCD00002196

  •  eCl@ss 39024506

  •  PubChem Substance ID 24901412

  •  NACRES NA.21

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Properties

Related Categories Alphabetical Listings, Flavors and Fragrances, Follows IFRA Guidelines, Halal Certified Products, Kosher Certified Products,
Quality Level   400
biological source   synthetic
grade   Halal
  Kosher
Agency/Method   follows IFRA guidelines
reg. compliance   EU Regulation 1223/2009
  EU Regulation 1334/2008 & 178/2002
  EU Regulation 178/2002
  FCC
  FDA 21 CFR 172.615
  FDA 21 CFR 175.125
  FDA 21 CFR 175.300
  FDA 21 CFR 175.380
  FDA 21 CFR 175.390
  FDA 21 CFR 184.1660
assay   ≥98%
mp   146-149 °C (lit.)
Documentation   see Safety & Documentation for available documents
Organoleptic   odorless
food allergen   no known allergens
fragrance allergen   no known allergens
storage temp.   room temp
SMILES string   CCCOC(=O)c1cc(O)c(O)c(O)c1
InChI   1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3
InChI key   ZTHYODDOHIVTJV-UHFFFAOYSA-N

Description

General description

Propyl gallate is mainly used as an antioxidant for edible fats and vegetable oils. It occurs naturally in the pods of tara tree.

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Packaging

1 kg in poly bottle

10 kg in fiber drum

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Other Notes

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
LW8400000
Flash Point(F) 
368.6 °F - closed cup
Flash Point(C) 
187 °C - closed cup
Protocols & Articles

Articles

Understanding the Complexities of Kosher Ingredients

Introduction What is Kosher Product Considerations for Kosher Certification Kosher's Added Benefit to the Food Industry Sigma-Aldrich's Kosher Experience and Offering
Dr. Luke Grocholl1, Rabbi Gershon Segal

1Dr. Luke Grocholl, Quality Assurance Supervisor, Sigma-Aldrich Flavors & Fragrances
Keywords: Fermentation, Food & Beverage, Safety industry

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Flavors and Fragrances Quality and Regulatory

From a comprehensive vendor approval process, to the testing of raw material at receipt as well as when product is ready to be shipped; we prove our dedication to supply chain transparency, every day.
Keywords: Allergens, Food Safety, Solvents

Peer-Reviewed Papers
15

References

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