699800P Avanti


Monophosphoryl Lipid A (Synthetic) (PHAD®), powder

Synonym: PHAD® phosphorylated hexaacyl disaccharide; Glycopyranoside Lipid A; GLA

  • CAS Number 1246298-63-4

  • Empirical Formula (Hill Notation) C96H184N3O22P

  • Molecular Weight 1763.47

  •  NACRES NA.25



Related Categories Avanti Adjuvants, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (HPLC)
form   powder
packaging   pkg of 1 × 1 mg (699800P-1mg)
  pkg of 1 × 5 mg (699800P-5mg)
mfr. no.   Avanti Polar Lipids, 699800P
shipped in   dry ice
storage temp.   −20°C


General description

Monophosphoryl lipid A (MPLA) is either extracted from bacterial lipid A or by chemical synthesis.

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD®), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.


MPLA PHAD® has been used:
• as a component of cobalt porphyrin-phospholipid (Co-PoP) liposomes for the immunization of mice with membrane proximal external region (MPER) of the gp41 envelope protein
• as an adjuvant along with dimethyldioctadecylammonium bromide(DDA) for C. muridarum recombinant membrane protein based multi-subunit vaccine
• as toll-like receptor-4 (TLR4) agonist adjuvant for respiratory syncytial virus (RSV) fusion (F) protein FI-RSV vaccine

Biochem/physiol Actions

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. MPLA used in vaccination improves B cell and T cell-mediated immunity.


2 mL Amber Glass Crimp Cap Vial (699800P-1mg)

2 mL Amber Glass Crimp Cap Vial (699800P-5mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

PHAD is a registered trademark of Avanti Polar Lipids, Inc.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents


General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers


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