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699851P Avanti

3A-MPLA

Monophosphoryl Tri-acyl Lipid A (Synthetic), powder

  • CAS Number 1699735-80-2

  • Empirical Formula (Hill Notation) C54H106N3O17P

  • Molecular Weight 1100.40

  •  NACRES NA.25

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Properties

Related Categories Avanti Adjuvants, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (HPLC)
form   powder
packaging   pkg of 1 × 1 mg (699851P-1mg)
  pkg of 1 × 5 mg (699851P-5mg)
mfr. no.   Avanti Polar Lipids, 699851P
shipped in   dry ice
storage temp.   −20°C
SMILES string   O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

Description

General description

Monophosphoryl lipid A (MPLA) is an analog of the lipid A moiety. It is regarded as a detoxified derivative of the lipopolysaccharide (LPS).

Biochem/physiol Actions

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.

Packaging

2 mL Amber Glass Crimp Cap Vial (699851P-1mg)

2 mL Amber Glass Crimp Cap Vial (699851P-5mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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