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700054P Avanti

5α,6β-dihydroxycholestanol

Cholestane-3β,5α,6β-triol, powder

Synonym: 3β,5α,6β-trihydroxycholestane

  • CAS Number 1253-84-5

  • Empirical Formula (Hill Notation) C27H48O3

  • Molecular Weight 420.67

  •  NACRES NA.25

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Properties

Related Categories Avanti Polar Lipids Products, Avanti Sterols, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
form   powder
packaging   pkg of 1 × 25 mg (700054P-25mg)
  pkg of 1 × 5 mg (700054P-5mg)
mfr. no.   Avanti Polar Lipids, 700054P
shipped in   dry ice
storage temp.   −20°C
InChI   1S/C27H48O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28-30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,25-,26-,27+/m1/s1
InChI key   YMMFNKXZULYSOQ-RUXQDQFYSA-N

Description

General description

5α,6β-dihydroxycholestanol is a structural derivative of cholesterol. It is produced by the low-density lipoprotein oxidation (LDL) and is a cholesterol autooxidation product. 5α,6β-dihydroxycholestanol is an abundant oxysterol.

Application

5α,6β-dihydroxycholestanol has been used as a cholesterol oxidation product in reversed phase chromatography (RP-HPLC) and mass spectroscopy analysis. It may be used as an internal standard in tandem mass spectrometry (MS/MS analysis) of plasma samples.

Biochem/physiol Actions

5α,6β-dihydroxycholestanol (5α,6α-diOH-Chol) or cholestan-3β,5α,6β-triol (C-triol) levels are elevated along with 7-ketocholesterol in Niemann-Pick type C (NP-C) disease and is a key biomarkers for detection. It exhibits neuroprotective functionality during central nervous system (CNS) ischemia.

Packaging

5 mL Amber Glass Screw Cap Vial (700054P-25mg)

5 mL Amber Glass Screw Cap Vial (700054P-5mg)

Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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