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700112P Sigma-Aldrich

7α-hydroxycholestenone-d7

7α-hydroxy-4-cholesten-3-one-d7, powder

Synonym: 25,26,26,26,27,27,27-heptadeutero-7α-hydroxy-4-cholesten-3-one ; 111106

  • Empirical Formula (Hill Notation) C27H37D7O2

  • Molecular Weight 407.68

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Properties

Related Categories Avanti Deuterium Labeled Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
form   powder
packaging   pkg of 1 × 1 mg (700112P-1mg)
  pkg of 1 × 10 mg (700112P-10mg)
  pkg of 1 × 5 mg (700112P-5mg)
mfr. no.   Avanti Polar Lipids, 700112P
shipped in   dry ice
storage temp.   −20°C

Description

Packaging

5 mL Amber Glass Screw Cap Vial (700112P-10mg)

5 mL Amber Glass Screw Cap Vial (700112P-1mg)

5 mL Amber Glass Screw Cap Vial (700112P-5mg)

General description

7α-Hydroxy-4-cholesten-3-one is an intermediate in the biochemical synthesis of bile acids from cholesterol. Its precursor, 7α-hydroxycholesterol, is produced from cholesterol by hepatic cholesterol 7α-hydroxylase (CYP7A1).[1]It is metabolized by the enzyme 7α-hydroxycholest-4-en-3-one 12α-hydroxylase to 7α,12α-dihydroxycholest-4-en-3-one and then to cholic acid, the major primary bile acid in humans. Alternatively, it can be converted into 5β-cholestane-3α,7α-diol and then to chenodeoxycholic acid, the other major primary bile acid in humans.Serum 7α-hydroxy-4-cholesten-3-one concentrations reflect the activity of the bile acid synthetic pathway. Serum 7α-hydroxy-4-cholesten-3-one values vary during the day as bile acid synthetic rates have a diurnal rhythm.[2]Elevated values are found in patients with bile acid malabsorption and may be useful in the diagnosis of this condition as high values are associated with low SeHCAT retention.[3] The increase in serum 7α-hydroxy-4-cholesten-3-one concentrations reflects the loss of bile acids secondary to bile acid malabsorption or the increased synthesis found in primary bile acid diarrhea associated with impaired negative feedback of CYP7A1 by FGF19.[4]

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Webinar - Hydrogels
Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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