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810207X Avanti

NBD Sphingosine-1-Phosphate

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine-1-phosphate, chloroform:methanol:water (65:25:4)

  • CAS Number 799268-48-7

  • Empirical Formula (Hill Notation) C24H40N5O8P

  • Molecular Weight 557.58

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Properties

Related Categories Avanti Fluorescent Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
packaging   pkg of 1 × 1 mL (810207X-100ug)
  pkg of 1 × 1 mL (810207X-50ug)
mfr. no.   Avanti Polar Lipids, 810207X
concentration   0.05 mg/mL (810207X-50ug)
  0.1 mg/mL (810207X-100ug)
shipped in   dry ice
storage temp.   −20°C

Description

General description

Sphingosine-1-phosphate is a phosphorylated sphingosine analog and is polar. It is terminally labelled by fluorescent nitrobenzo-2-oxa-1,3-diazole (NBD) group. Sphingosine-1-phosphate is abundantly stored in platelets.

Application

NBD sphingosine-1-phosphate has been used as a substrate in the detection of sphingosine-1-phosphate phosphatases (SPPase) enzymatic activity by in vitro assay.

Biochem/physiol Actions

Sphingosine-1-phosphate (S1P) initiates DNA synthesis. It is also involved in cell division, cell growth and platelet activation. S1P mediates cell movement, differentiation and survival. It specifically stimulates endothelial cells.

Packaging

5 mL Amber Glass Screw Cap Vial (810207X-100ug)

5 mL Amber Glass Screw Cap Vial (810207X-50ug)

Safety & Documentation

Safety Information

RIDADR 
UN 1992 6.1(3) / PGII

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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