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810258E Avanti

C11 TopFluor® GM3

C11 TopFluor GM3 Ganglioside (ammonium salt), ethanol solution

  • CAS Number 2260795-48-8

  • Empirical Formula (Hill Notation) C65H110BF2N5O21

  • Molecular Weight 1346.40

  •  NACRES NA.25

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Properties

Related Categories Avanti Fluorescent Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
form   ethanol solution
packaging   pkg of 1 × 1 mL (810258E-100ug)
mfr. no.   Avanti Polar Lipids, 810258E
concentration   0.1 mg/mL (810258E-100ug)
shipped in   dry ice
storage temp.   −20°C

Description

General description

C11 TopFluor® GM3 is a fluorescent analog of ganglioside GM3 (Siaa2-3Galb1-4Glcb1-1Cer).

Application

C11 TopFluor® GM3 has been used to visualize GM3 present in UGCG-KO1.3 cells by immunofluorescence microscopy.

Biochem/physiol Actions

Gangliosides function as modulators in regulating various receptor functions, involved in transmembrane signaling. GM3 plays an important role as a metabolic precursor for the formation of more complex gangliosides. It comprises between 80% and 90% of total ganglioside content in liver and adipose tissue, respectively. Additionally, GM3 is known to promote the subcellular redistribution of major caveolin enriched microdomain (CEM) components coordinating signal transduction. The increased levels of ganglioside GM3 in serum is reported in hyperlipidaemic, hyperglycaemic and type 2 diabetic patients.

Packaging

5 mL Amber Glass Screw Cap Vial (810258E-100ug)

Legal Information

TopFluor is a registered trademark of Avanti Polar Lipids, Inc.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany 
WGK 1
Flash Point(F) 
55.4 °F - closed cup
Flash Point(C) 
13.0 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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