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810314P Avanti

NBD Phytosphingosine

Omega-NBD D-ribo-Phytosphingosine, powder

Synonym: (2S,3S,4R)-2-amino-18-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)octadecane-1,3,4-triol

  • CAS Number 2260669-58-5

  • Empirical Formula (Hill Notation) C24H41N5O6

  • Molecular Weight 495.61

  •  NACRES NA.25

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Properties

Related Categories Avanti Fluorescent Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
form   powder
packaging   pkg of 1 × 100 μg (810314P-100ug)
  pkg of 1 × 250 μg (810314P-250ug)
  pkg of 1 × 50 μg (810314P-50ug)
mfr. no.   Avanti Polar Lipids, 810314P
shipped in   dry ice
storage temp.   −20°C

Description

General description

Phytosphingosine (PHS) is one of the important constituent of phytoceramides. This sphingoid has a hydroxyl group at C-4 of the sphingoid long-chain base. PHS is a component of mammalian epidermis and is widely distributed in fungi and plants. Nitrobenzoxadiazole/7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) is a fluorescent conjugate.

Application

NBD Phytosphingosine has been used as a substrate in ceramide synthase assays.

Biochem/physiol Actions

Phytosphingosine (PHS) is capable of activating G-protein coupled receptor 120 (GPR120). Treating cultured keratinocytes (KC) with PHS can enhance the content of ceramide NP. It plays as key role in epidermal differentiation and also possesses anti-inflammatory and antimicrobial activities.

Packaging

5 mL Amber Glass Screw Cap Vial (810314P-100ug)

5 mL Amber Glass Screw Cap Vial (810314P-250ug)

5 mL Amber Glass Screw Cap Vial (810314P-50ug)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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