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850174P Avanti

06:0 PI(3,5)P2

1,2-dihexanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,5′-bisphosphate) (ammonium salt), powder

Synonym: PIP2[3′,5′](6:0/6:0)

  • CAS Number 799268-61-4

  • Empirical Formula (Hill Notation) C21H50N3O19P3

  • Molecular Weight 741.55

  •  NACRES NA.25

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Properties

Related Categories Avanti PI, PIP & LPI, Avanti Phospholipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids More...
assay   >99% (TLC)
form   powder
packaging   pkg of 1 × 100 μg (with stopper and crimp cap (850174P-100ug))
  pkg of 1 × 500 μg (with stopper and crimp cap (850174P-500ug))
mfr. no.   Avanti Polar Lipids, 850174P
shipped in   dry ice
storage temp.   −20°C
SMILES string   [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCC)=O)COC(CCCCC)=O.[NH4+].[NH4+].[NH4+]

Description

General description

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is an inositol phospholipid, which accounts for approximately 0.05-0.1% of total cellular phosphatidylinositol (PI). In fungi and higher eukaryotes, this less abundant phosphoinositide is present in the endosomal and lysosomal membranes.

Biochem/physiol Actions

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is capable of activating ion channels on endosomes and lysosomes. It also activates mammalian target of rapamycin complex 1 (mTORC1) in yeast and in some mammalian cell types.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850174P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850174P-500ug)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

Determination of Phospholipid Oxidation by UV/VIS Spectroscopy - Avanti® Polar Lipids

The percent oxidation of a phospholipid can be determined by using Beer’s Law to calculate the peroxidized phospholipid’s concentration from its absorbance at 234 nm.
Keywords: Extinction coefficient, Oxidations

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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