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850336P Avanti

MAPCHO®-12

n-dodecylphosphocholine, powder

Synonym: DPC; Fos-Choline-12; FOS12; FC-12

  • CAS Number 29557-51-5

  • Empirical Formula (Hill Notation) C17H38NO4P

  • Molecular Weight 351.46

  •  NACRES NA.25

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Properties

Related Categories Avanti Bioactive Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
form   powder
packaging   pkg of 1 × 1 g (850336P-1g)
  pkg of 1 × 25 g (850336P-25g)
  pkg of 1 × 5 g (850336P-5g)
mfr. no.   Avanti Polar Lipids, 850336P
shipped in   dry ice
storage temp.   −20°C
InChI   1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3
InChI key   QBHFVMDLPTZDOI-UHFFFAOYSA-N

Description

General description

Dodecylphosphocholine is a structural analog of lauroyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification.Dodecylphosphocholine has been shown to improve paracellular permeability of hydrophilic compounds by modulating the tight junctions. This may have implications on its use for oral or nasal drug delivery.

MAPCHO®-12 or n-dodecylphosphocholine is a detergent with short chain.

Application

MAPCHO®-12 is suitable for use as detergent for B. subtilis cytochrome b558 protein for nuclear magnetic resonance experiments. It is also suitable for use in the purification of cytoplasmic tail of gp41 (gp41CT) protein and micelle preparation.

Biochem/physiol Actions

MAPCHO®-12 or n-dodecylphosphocholine in combination with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is used for membrane-mimetic bicelle system for orientation based studies in membrane proteins. It provides a zwitterionic surface in the membrane micelle structure.

Packaging

125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850336P-5g)

20 mL Clear Glass Screw Cap Vial (850336P-1g)

250 mL Amber Wide Mouth Glass Bottle with Screw Cap (850336P-25g)

Legal Information

MAPCHO is a registered trademark of Avanti Polar Lipids, Inc.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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