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850345C Avanti

14:0 PC (DMPC)

1,2-dimyristoyl-sn-glycero-3-phosphocholine, chloroform

Synonym: 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine; DMPC; PC(14:0/14:0)

  • CAS Number 18194-24-6

  • Empirical Formula (Hill Notation) C36H72NO8P

  • Molecular Weight 677.93

  •  NACRES NA.25

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Properties

Related Categories Avanti PC & LPC, Avanti Phospholipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids More...
assay   >99% (TLC)
packaging   pkg of 1 × 2.5 mL (850345C-25mg)
  pkg of 1 × 20 mL (850345C-500mg)
  pkg of 2 × 20 mL (850345C-1g)
  pkg of 2 × 4 mL (850345C-200mg)
mfr. no.   Avanti Polar Lipids, 850345C
concentration   10 mg/mL (850345C-25mg)
  25 mg/mL (850345C-1g)
  25 mg/mL (850345C-200mg)
  25 mg/mL (850345C-500mg)
shipped in   dry ice
storage temp.   −20°C
InChI   1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3/t34-/m0/s1
InChI key   CITHEXJVPOWHKC-UMSFTDKQSA-N

Description

General description

Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon.

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

14:0 PC (DMPC) has been used in liposome preparation. It is also suitable for use:
• in the preparation of lipid bicelles for nuclear magnetic resonance (NMR) experiments
• in labeled vesicle preparation for fluorescence polarization measurements
• as internal standard (IS) for the quantitation of phosphatidylcholine (PC) by liquid chromatography with tandem mass spectrometry (LC-MS-MS)

Biochem/physiol Actions

Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850345C-1g)

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850345C-500mg)

5 mL Clear Glass Sealed Ampule (850345C-200mg)

5 mL Clear Glass Sealed Ampule (850345C-25mg)

Safety & Documentation

Safety Information

RIDADR 
UN 1888 6.1 / PGIII

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

Determination of Phospholipid Oxidation by UV/VIS Spectroscopy - Avanti® Polar Lipids

The percent oxidation of a phospholipid can be determined by using Beer’s Law to calculate the peroxidized phospholipid’s concentration from its absorbance at 234 nm.
Keywords: Extinction coefficient, Oxidations

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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