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850355P Avanti

16:0 PC (DPPC)

1,2-dipalmitoyl-sn-glycero-3-phosphocholine, powder

Synonym: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine; DPPC; PC(16:0/16:0)

  • CAS Number 63-89-8

  • Empirical Formula (Hill Notation) C40H80NO8P

  • Molecular Weight 734.04

  •  NACRES NA.25

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Properties

Related Categories Avanti PC & LPC, Avanti Phospholipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids More...
assay   >99% (TLC)
form   powder
packaging   pkg of 1 × 1 g (850355P-1g)
  pkg of 1 × 200 mg (850355P-200mg)
  pkg of 1 × 25 mg (850355P-25mg)
  pkg of 1 × 500 mg (850355P-500mg)
mfr. no.   Avanti Polar Lipids, 850355P
shipped in   dry ice
storage temp.   −20°C
SMILES string   [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O
InChI   1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3
InChI key   KILNVBDSWZSGLL-UHFFFAOYSA-N

Description

General description

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) is synthesized from unsaturated phosphatidylcholine (PC) by direct de novo synthesis via α1,2-dipalmitoyl diacylglycerol intermediate. The enzyme cholinephosphotransferase catalyzes the conversion of 1,2-dipalmitoyl diacylglycerol to DPPC. Synthesis of DPPC also occurs via remodeling pathway involving deacylation of unsaturated PC.

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

16:0 PC (DPPC) has been used in the generation of thymoquinone (TQ) liposomes, gold nanorods and calcium chloride encapsulated liposomes and bilayers for biophysical studies.

Biochem/physiol Actions

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) is a surfactant and reduces surface tension. It is used in combination with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) for lipid bilayer generation. DPPC alone and in combination with other phospholipid is effective in drug encapsulation and delivery.

Packaging

20 mL Clear Glass Screw Cap Vial (850355P-1g)

20 mL Clear Glass Screw Cap Vial (850355P-500mg)

5 mL Amber Glass Screw Cap Vial (850355P-200mg)

5 mL Amber Glass Screw Cap Vial (850355P-25mg)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

Determination of Phospholipid Oxidation by UV/VIS Spectroscopy - Avanti® Polar Lipids

The percent oxidation of a phospholipid can be determined by using Beer’s Law to calculate the peroxidized phospholipid’s concentration from its absorbance at 234 nm.
Keywords: Extinction coefficient, Oxidations

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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