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850520P Avanti

n-dodecyl-β-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside, powder

Synonym: DDM; lauryl maltoside; dodecyl 4-O-α-D-glucopyranosyl-β-D-glucopyranoside

  • CAS Number 69227-93-6

  • Empirical Formula (Hill Notation) C24H46O11

  • Molecular Weight 510.62

  •  NACRES NA.25

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Properties

Related Categories Avanti Detergents, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (contains <2% alpha isomer, TLC)
form   powder
mol wt   510.62 g/mol
packaging   pkg of 1 × 1 g (850520P-1g)
  pkg of 1 × 25 g (850520P-25g)
  pkg of 1 × 5 g (850520P-5g)
mfr. no.   Avanti Polar Lipids, 850520P
shipped in   dry ice
storage temp.   −20°C
SMILES string   OC[C@H]1O[C@@H](OCCCCCCCCCCCC)[C@H](O)[C@@H](O)[C@@H]1O[C@@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2
InChI   1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1
InChI key   NLEBIOOXCVAHBD-QKMCSOCLSA-N

Description

General description

n-dodecyl-β-D-maltoside (DDM) is a sugar-based surfactant.

DDM is the most widely used detergent for the isolation and purification of GPCR’s. In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form.

Application

n-dodecyl-β-D-maltoside (DDM) has been used to solubilize mitochondrial extracts of fibroblasts to perform one-dimensional blue-native PAGE (BN-PAGE) analysis for assembled oxidative phosphorylation (OXPHOS) complexes.

Biochem/physiol Actions

n-dodecyl-β-D-maltoside (DDM) exhibits biocompatibility and biodegradability. It serves as a facilitator of electron transfer in order to decrease the oxidation potential of 3,4-ethylenedioxythiophene (EDOT). It can also increase the solubility of EDOT in aqueous solution.

Packaging

125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850520P-25g)

20 mL Clear Glass Screw Cap Vial (850520P-1g)

30 mL Amber Wide Mouth Screw Cap Glass Bottle (850520P-5g)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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