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857392O Avanti

(R)-FTY720-OMe

(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil

Synonym: (R)-FTY720-methyl ether; ROME

  • CAS Number 1382486-90-9

  • Empirical Formula (Hill Notation) C20H35NO2

  • Molecular Weight 321.50

  •  NACRES NA.25

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Properties

Related Categories Avanti Bioactive Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
assay   >99% (TLC)
packaging   pkg of 1 × 1 mg (857392O-1mg)
mfr. no.   Avanti Polar Lipids, 857392O
shipped in   dry ice
storage temp.   −20°C

Description

General description

(R)-FTY720-OMe is the analogue of FTY720.

(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.

Biochem/physiol Actions

(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.

Packaging

5 mL Amber Glass Screw Cap Vial (857392O-1mg)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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