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860463P Avanti

N-C16-desoxymethylsphinganine

N-palmitoyl-1-desoxymethylsphinganine (m17:0/16:0), powder

  • CAS Number 1246298-42-9

  • Empirical Formula (Hill Notation) C33H67NO2

  • Molecular Weight 509.89

  •  NACRES NA.25

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Properties

Related Categories Avanti Polar Lipids Products, Avanti Sphingolipids, Avanti Sphingolipids & Ceramides, Biochemicals and Reagents, Lipids More...
form   powder
packaging   pkg of 1 × 1 mg (860463P-1mg)
  pkg of 1 × 5 mg (860463P-5mg)
mfr. no.   Avanti Polar Lipids, 860463P
shipped in   dry ice
storage temp.   −20°C
SMILES string   [H][C@](CCCCCCCCCCCCCCC)(O)CNC(CCCCCCCCCCCCCCC)=O

Description

General description

N-C16-desoxymethylsphinganine is the N-acylated form of 1-desoxymethylsphinganine, a potent inhibitor of sphingolipid metabolism. Ceramide synthases (CerS) catalyzes the acylation of sphingoid bases using fatty acyl-CoA and its inhibition results in decrease of N-acylsphinganines (dihydroceramides) levels and accumulation of sphinganine. Dihydroceramides (DHCer) are intermediates of ceramide biosynthesis.

Biochem/physiol Actions

Dihydroceramides are also used for dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.

Packaging

5 mL Amber Glass Screw Cap Vial (860463P-1mg)

5 mL Amber Glass Screw Cap Vial (860463P-5mg)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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