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860480P Avanti

C10 bisphosphonate

1-aminodecane-1,1-bisphosphonic acid, powder

  • CAS Number 15049-93-1

  • Empirical Formula (Hill Notation) C10H25NO6P2

  • Molecular Weight 317.26

  •  NACRES NA.25

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Properties

Related Categories Avanti Polar Lipids Products, Avanti Sphingolipids, Avanti Sphingolipids & Ceramides, Biochemicals and Reagents, Lipids More...
form   powder
packaging   pkg of 1 × 500 μg (860480P-500ug)
mfr. no.   Avanti Polar Lipids, 860480P
shipped in   dry ice
storage temp.   −20°C
SMILES string   [NH3+]C(P([O-])(O)=O)(P(O)(O)=O)CCCCCCCCC

Description

Application

C10 bisphosphonate is suitable for use as an inhibitor for acid sphingomyelinase.

Biochem/physiol Actions

C10 bisphosphonate, with prolonged carbon chain, is an inhibitor for acid sphingomyelinase and may be a treatment option for inflammatory lung diseases, cystic fibrosis and atherosclerosis. It interacts with the divalent metal ions and forms bidentate complexes. Bisphosphonates are inhibitors of end reaction in pathways. It is an inhibitor of cytosolic farnesyl diphosphate (FDP) synthase (geranyl diphosphate (GDP) and geranylgeranyl diphosphate (GGDP) synthase and isoprene pathway. Bisphosphonates have antimicrobial functionality and inhibits the growth of Entamoeba histolytica and Plasmodium falciparum.

Packaging

5 mL Amber Glass Screw Cap Vial (860480P-500ug)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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