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860665P Avanti

4E,14Z-Sphingadiene

(2S,3R,4E,14Z)-2-aminooctadec-4,14-diene-1,3-diol, powder

  • CAS Number 25696-03-1

  • Empirical Formula (Hill Notation) C18H35NO2

  • Molecular Weight 297.48

  •  NACRES NA.25

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Properties

Related Categories Avanti Polar Lipids Products, Avanti Sphingolipids, Avanti Sphingolipids & Ceramides, Biochemicals and Reagents, Lipids More...
form   powder
packaging   pkg of 1 × 1 mg (860665P-1mg)
mfr. no.   Avanti Polar Lipids, 860665P
shipped in   dry ice
storage temp.   −20°C
SMILES string   OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCC/C=C\CCC
InChI   1S/C18H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h4-5,14-15,17-18,20-21H,2-3,6-13,16,19H2,1H3/b5-4-,15-14+
InChI key   KWDXKYNWAKMLKK-YQMRQDNGSA-N

Description

General description

4E,14Z-Sphingadiene is a unique sphingoid base containing C18 chain, with trans double bond at C-4 and cis double bond between C14 and C15 with a bent structure. It is found in the plasma, lymph, brain, kidney and lungs of humans and mice. 4E,14Z-Sphingadiene or d-erythro-1,3-dihydroxy-2-amino-4-trans-14-cis-octadecadiene is the second largest long-chain base of human plasma sphingomyelins.

Biochem/physiol Actions

Sphingadiene, a vital component of sphingolipids facilitates numerous processes such as apoptosis and cell signaling. It inhibits Akt/Wnt signaling and acts as an anticancer agent in colon cancer.

Packaging

5 mL Amber Glass Screw Cap Vial (860665P-1mg)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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