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867000P Avanti

KRN7000

α-Galactosyl Ceramide, powder

  • CAS Number 158021-47-7

  • Empirical Formula (Hill Notation) C50H99NO9

  • Molecular Weight 858.32

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Properties

Related Categories Avanti Ceramides, Avanti Polar Lipids Products, Avanti Sphingolipids & Ceramides, Biochemicals and Reagents, Lipids More...
form   powder
packaging   pkg of 1 × 1 mg (867000P-1mg)
mfr. no.   Avanti Polar Lipids, 867000P
shipped in   dry ice
storage temp.   −20°C

Description

General description

α-Galactosyl Ceramide (KRN7000) is a high affinity glycolipid ligand for invariant natural killer T cell (iNKT). It has  α-galactosyl ceramide core  and is a variant of agelasphin-9b ceramide core. It is a synthetic homolog of α‐GalCer from marine sponges. It comprises long fatty acyl chain (C26) and sphingosine base (C18).

Application

α-Galactosyl Ceramide (KRN7000) has been used in the in-vitro stimulation of natural killer cells. It is suitable for use as a lipid antigen in bone marrow derived cells (BMDC) and hepatocyte primary cells prior to antigen presentation assay. It is also suitable for use as a ligand invariant natural killer T cell activation.

Biochem/physiol Actions

α-Galactosyl Ceramide (KRN7000) administration results in T helper (TH0) or TH2 cytokine response. it displays potent antitumor activity in various in vivo models such as B6 melanoma, colon26 adenocarcinoma and hepatic metastases.

Packaging

5 mL Amber Glass Screw Cap Vial (867000P-1mg)

Other Notes

Not available in Japan

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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