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870606P Avanti

POVPC

1-palmitoyl-2-(5′-oxo-valeroyl)-sn-glycero-3-phosphocholine, powder

  • CAS Number 121324-31-0

  • Empirical Formula (Hill Notation) C29H56NO9P

  • Molecular Weight 593.73

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Properties

Related Categories Avanti Bioactive Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
form   powder
packaging   pkg of 1 × 1 mg (870606P-1mg)
mfr. no.   Avanti Polar Lipids, 870606P
shipped in   dry ice
storage temp.   −20°C

Description

General description

1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) is a derivative of oxidized Low density lipoprotein (oxLDL), a proinflammatory lipid present in atherosclerotic lesions.

Application

1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) has been used:
• to study its effects on endothelial function and vasodilation
• as a ligand for LRP6 in bone marrow mesenchymal stromal cells (MSCs)
• as a oxidized lipid to study if membrane status at different degrees of lipid peroxidation is involved in oxidative stress tolerance

Biochem/physiol Actions

1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) affects endothelial function by hindering activity of endothelial nitric oxide synthase and stimulating endothelial cell apoptosis. It is implicated in the development of atherosclerosis and it may be used as a potent therapeutic for atherosclerosis.

Packaging

5 mL Clear Glass Sealed Ampule (870606P-1mg)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Storage & Handling of Lipids - Avanti® Polar Lipids

The following statements pertain specifically to Avanti’s lipid products for research and should not necessarily be applied to cGMP lipids intended for pharmaceutical or diagnostic applications.
Keywords: Diagnostic, Oxidations, Pharmaceutical, Solvents

Protocols

General Lipid/BSA Solubilization Protocol For Cell Delivery

Water Solutions: Solubilizing some lipids is difficult using organic solvents. Typically, lipids are suspended in methanol to aliquot, the methanol is then dried and the residue dispersed using fatty...
Keywords: Evaporation, Solvents

Peer-Reviewed Papers
15

References

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