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870865P Avanti

BMP22

4-pentadecylbenzylphosphonic acid, powder

  • Empirical Formula (Hill Notation) C22H39O3P

  • Molecular Weight 382.52

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Properties

Related Categories Avanti Bioactive Lipids, Avanti Polar Lipids Products, Biochemicals and Reagents, Lipids
form   powder
packaging   pkg of 1 × 1 mg (870865P-1mg)
  pkg of 1 × 5 mg (870865P-5mg)
mfr. no.   Avanti Polar Lipids
application(s)   thin layer chromatography (TLC): 99%
shipped in   dry ice
storage temp.   −20°C
SMILES string   CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1

Description

General description

BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.

Biochem/physiol Actions

BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.

Packaging

5ML Glass Amber Screw Cap Vial (870865P-1MG)

5ML Glass Amber Screw Cap Vial (870865P-5MG)

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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