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C-015 Supelco

Codeine solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

  • CAS Number 76-57-3

  • Empirical Formula (Hill Notation) C18H21NO3

  • Molecular Weight 299.36

  •  EC Number 200-659-6

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs), Certified Reference Materials from Cerilliant,
grade   certified reference material
InChI Key   OROGSEYTTFOCAN-DNJOTXNNSA-N
feature   SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
drug control   Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
concentration   100 μg/mL in methanol
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   2-8°C

Description

General description

Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. This certified reference solution is suitable for use as a starting material in calibrators and controls for LC/MS and GC/MS testing methods in clinical toxicology, forensic analysis, pharmaceutical research, and pain prescription monitoring. As a widely popular recreational drug, codeine is regulated under various narcotic control laws in countries such as Australia, New Zealand, Romania, Sweden, and the United States. Since opiates are classified as controlled substances, Cerilliant offers most opiate reference standards as DEA-exempt solutions for added convenience.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
48.2 °F
Flash Point(C) 
9 °C

Documents

Certificate of Analysis

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Protocols & Articles

Articles

GC Analysis of Basic Drugs on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on Equity®-5
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GC Analysis of Basic Drugs on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm) after SPME using 65 μm PDMS/DVB Fiber, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm) after SPME using 65 μm PDMS/DVB Fiber, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification, Solid phase microextractions

GC Analysis of Basic Drugs on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Alkaloids on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Alkaloids on Discovery® RP-AmideC16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Alkaloids on Discovery® Zr-PBD

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Alkaloids on Discovery® Zr-PBD
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Amides on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Amides on Discovery® RP-Amide C16
Keywords: Analgesics, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Analgesics on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Analgesics on Discovery® RP-Amide C16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Analgesics, Narcotics on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Analgesics, Narcotics on Ascentis® Phenyl
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antitussive/Antihistamine/Antipyretic Mix on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antitussive/Antihistamine/Antipyretic Mix on Discovery® RP-Amide C16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Codeine and Metabolite on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Codeine and Metabolite on Ascentis® C18
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Codeine and Metabolite on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Codeine and Metabolite on Ascentis® RP-Amide
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Cold Remedy Components on Ascentis® Express 2.0 μm RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cold Remedy Components on Ascentis® Express 2.0 μm RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Drugs of Abuse on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Drugs of Abuse on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Drugs of Abuse on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Drugs of Abuse on Ascentis® Phenyl
Keywords: Chromatography, High performance liquid chromatography

LC-MS Analysis of Pain Management Opiates using Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC-MS Analysis of Pain Management Opiates using Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Separation

LC-MS Anlaysis of Pain Managment Opiates on Ascentis® Express Biphenyl, 30 x 2.1 mm

From our library of Articles, Sigma-Aldrich presents LC-MS Anlaysis of Pain Managment Opiates on Ascentis® Express Biphenyl, 30 x 2.1 mm
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Separation

LC/MS (TOF) Analysis of Opioid Drugs and Glucuronide Metabolites in Urine on Ascentis® Express HILIC after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Opioid Drugs and Glucuronide Metabolites in Urine on Ascentis® Express HILIC after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Metabolites, Sample preparations, Solid phase extractions

LC/MS (TOF) Analysis of Opioids and Opiate-Dependence Management Drugs on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Opioids and Opiate-Dependence Management Drugs on Ascentis® Express HILIC
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

LC/MS Analysis of Opioid Glucuronide Metabolites in Urine on Ascentis® Express F5 after Solid Phase Extraction (SPE) using Supel™-Select HLB

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Opioid Glucuronide Metabolites in Urine on Ascentis® Express F5 after Solid Phase Extraction (SPE) using Supel™-Select HLB
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Sample preparations, Separation, Solid phase extractions, Solvents

LC/MS Analysis of Pain Management Opioids on Ascentis® Express Phenyl-Hexyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Pain Management Opioids on Ascentis® Express Phenyl-Hexyl
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites

LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase microextractions

LC/MS/MS Analysis of Drugs of Abuse: Generic Screening on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Drugs of Abuse: Generic Screening on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents

Medication Monitoring Testing

Prescription monitoring requires accurate reference standards to ensure consistent and reliable results for drug confirmation and monitoring compliance.
Keywords: Anti-depressants, Anticonvulsants, Cardiovascular, Clinical, Controlled substances, Diabetes, Forensic, Gas chromatography, High performance liquid chromatography, Ion-exchange chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Schizophrenia

Opiate Standards

Over the last decade, the prevalence of nonmedical prescription opioid and opiate use has increased worldwide and is the primary contributor to the global number of drug-related deaths. In the United...
Keywords: Controlled substances, Ion-exchange chromatography

Pharmaceutical and Drug Standards for Wastewater Testing

In 2008 an Associated Press investigation identified numerous pharmaceutical and personal care products in drinking water supplies of at least 41 million Americans. The publication of this report and...
Keywords: Anti-depressants, Environmental, Hormones, Ion-exchange chromatography, Metabolites, Pharmaceutical

TLC Analysis of Analgesics on HPTLC Pre-coated Plate RP-18 WF254s (analyte set 1)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Analgesics on HPTLC Pre-coated Plate RP-18 WF254s (analyte set 1)
Keywords: Pharmaceutical, Thin layer chromatography

TLC Analysis of Drugs on HPTLC Silica Gel 60 RP-18 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Drugs on HPTLC Silica Gel 60 RP-18 F254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

Related Products

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Description

Add to Cart

C-006 Codeine solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
A-053 6-Acetylcodeine solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
C-005 Codeine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C-007 Codeine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C-040 Codeine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C-041 Codeine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-071 Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®
O-020 Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®
C-087 Codeine-6-β-D-glucuronide solution, 100 μg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®
D-019 Dihydrocodeine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
D-021 Dihydrocodeine-D6 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
D-087 Dihydrocodeine-D6 hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
N-005 Norcodeine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
06693 Timestrip Plus -20 °C

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