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C-106 Supelco

Cortisol solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym: 17-Hydroxycorticosterone, Cortisol, Hydrocortisone solution

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Biomarkers and Metabolomics Standards, Certified Reference Materials (CRMs),
Quality Level   300
grade   certified reference material
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   1.0 mg/mL in methanol
format   single component solution
storage temp.   −20°C
SMILES string   C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
InChI   1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key   JYGXADMDTFJGBT-VWUMJDOOSA-N
Gene Information   human ... NR3C1(2908)

Description

General description

Also known as hydrocortisone, cortisol is a glucocorticoid produced by the adrenal gland. The hormone is measured in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing’s syndrome, Addison’s disease, and Sheehan’s syndrome.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
WGK 2
Flash Point(F) 
49.5 °F - closed cup
Flash Point(C) 
9.7 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Steroids on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Phenyl
Keywords: Chromatography, Clinical, High performance liquid chromatography

Hormone Standards

Over the past 17 years, hormone testing has increased significantly in the clinical laboratory setting as advances in the specificity and selectivity of LC-MS/MS technology have enabled hormones to s...
Keywords: Clinical, Clinical Chemistry, Diagnostic, Diseases, Endocrinology, High performance liquid chromatography, Hormones, Ion-exchange chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites

Mitigation of Deuterium Scrambling in Stable-Labeled Internal Standards during LC-MS MS Analysis

Improvements in LC-MS/MS sensitivity and multiple reaction monitoring (MRM) capabilities are resulting in further adoption of LC-MS/MS technology in clinical settings. One specific clinical challenge...
Authors: Joshua Cooper1, Billy Molloy2, Huahua Jian1, Lisa Calton2, Derrell Johnson1, Isil Dilek1, Uma Sreenivasan1, Don Cooper2
1Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock, TX 78665 2 Waters Corporation, Atlas Park, Simonsway, Manchester, M22 5 PP UKCONCLUSIONS
Keywords: Clinical, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Nuclear magnetic resonance spectroscopy, Phase transitions

Steroid Standards

Over the past 20 years the prevalence rate of illicit anabolic steroid use among US high school students has ranged from 2.2-6.1%.1 Anabolic steroids such as androstene, androsterone, boldenone and b...
Keywords: Cancer, Clinical, Clinical Chemistry, Diagnostic, Diseases, Endocrinology, High performance liquid chromatography, Hormones, Ion-exchange chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites

UHPLC Analysis of Corticosteroids on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Corticosteroids on Titan™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

UHPLC Analysis of Steroids on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Steroids on Ascentis® Express F5
Keywords: Separation

Peer-Reviewed Papers
15

References

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