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E-068 Supelco

Everolimus solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

  • CAS Number 159351-69-6

  • Empirical Formula (Hill Notation) C53H83NO14

  • Molecular Weight 958.22

  •  MDL number MFCD00929329

  •  PubChem Substance ID 329798983

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Immunosuppressants, Pharmaceuticals, Illicit Drugs & Alcohol
Quality Level   100
grade   certified reference material
feature   (Snap-N-Spike®)
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   1.0 mg/mL in acetonitrile
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
shipped in   dry ice
storage temp.   −70°C
InChI   1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
InChI key   HKVAMNSJSFKALM-GKUWKFKPSA-N
Gene Information   human ... FKBP1A(2280)

Description

General description

Everolimus, sold under trade names including Zortress®, Certican, and Afinitor®, is an immunosuppressant drug used to prevent rejection of organ transplants and to treat renal cell cancer and other tumors. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of everolimus in patient whole blood samples by LC-MS/MS.

Legal Information

Afinitor is a registered trademark of Novartis AG

CERILLIANT is a registered trademark of Cerilliant Corporation

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Zortress is a registered trademark of Novartis AG

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1648 3 / PGII
WGK Germany 
WGK 2
Flash Point(F) 
35.6 °F - closed cup
Flash Point(C) 
2.0 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Snap-N-Spike® reference solutions of immunosuppressant drugs

Immunosuppressant drugs including tacrolimus, sirolimus, everolimus, and cyclosporine diminish immune responses and are used worldwide to prevent organ rejection after transplantation. In the United ...
Keywords: Clinical, Diagnostic, Ion-exchange chromatography, Metabolites

Therapeutic Drug Monitoring Standards

Therapeutic drug monitoring (TDM) measures drug concentrations in blood and other biological fluids to ensure maintenance of a drug’s therapeutic range. TDM is performed routinely to guide the dosing...
Keywords: Anti-depressants, Anticonvulsants, Antifungals, Cancer, High performance liquid chromatography, Immunoassay, Ion-exchange chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Peer-Reviewed Papers
15

References

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E-070 Everolimus-D4 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
S-015 Sirolimus solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
T-049 Tacrolimus solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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