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H-003 Supelco

Hydrocodone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

  • CAS Number 125-29-1

  • Empirical Formula (Hill Notation) C18H21NO3

  • Molecular Weight 299.36

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs), Certified Reference Materials from Cerilliant,
Quality Level   100
grade   certified reference material
InChI Key   ZICRJLQTAUVSDU-NSJZFRMTSA-N
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
drug control   Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
concentration   1.0 mg/mL in methanol
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   −20°C

Description

General description

Hydrocodone is a semi-synthetic opioid derived from codeine or thebaine, two naturally-occurring opiates. The drug, also known as dihydrocodeinone, is used as an analgesic to treat pain and as an antitussive for coughing or related conditions. This Certified Spiking Solution® is suitable as a starting material for calibrators or controls in GC/MS or LC/MS testing applications from pharmaceutical research and pain prescription monitoring to clinical toxicology and forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
48.2 °F
Flash Point(C) 
9 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Drugs of Abuse on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Drugs of Abuse on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Drugs of Abuse on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Drugs of Abuse on Ascentis® Phenyl
Keywords: Chromatography, High performance liquid chromatography

LC-MS Analysis of Pain Management Opiates using Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC-MS Analysis of Pain Management Opiates using Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Separation

LC-MS Anlaysis of Pain Managment Opiates on Ascentis® Express Biphenyl, 30 x 2.1 mm

From our library of Articles, Sigma-Aldrich presents LC-MS Anlaysis of Pain Managment Opiates on Ascentis® Express Biphenyl, 30 x 2.1 mm
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Separation

LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 after Solid Phase Extraction (SPE) using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 after Solid Phase Extraction (SPE) using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion
Keywords: Analgesics, Anticonvulsants, Chromatography, Clinical, Digestions, High performance liquid chromatography, Mass spectrometry, Metabolites, Sample preparations, Solid phase extractions

LC/MS (TOF) Analysis of Opioid Drugs and Glucuronide Metabolites in Urine on Ascentis® Express HILIC after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Opioid Drugs and Glucuronide Metabolites in Urine on Ascentis® Express HILIC after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Metabolites, Sample preparations, Solid phase extractions

LC/MS (TOF) Analysis of Opioids and Opiate-Dependence Management Drugs on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Opioids and Opiate-Dependence Management Drugs on Ascentis® Express HILIC
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

LC/MS Analysis of Opioid Glucuronide Metabolites in Urine on Ascentis® Express F5 after Solid Phase Extraction (SPE) using Supel™-Select HLB

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Opioid Glucuronide Metabolites in Urine on Ascentis® Express F5 after Solid Phase Extraction (SPE) using Supel™-Select HLB
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Sample preparations, Separation, Solid phase extractions, Solvents

LC/MS/MS Analysis of Drugs of Abuse: Generic Screening on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Drugs of Abuse: Generic Screening on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents

Medication Monitoring Testing

Prescription monitoring requires accurate reference standards to ensure consistent and reliable results for drug confirmation and monitoring compliance.
Keywords: Anti-depressants, Anticonvulsants, Cardiovascular, Clinical, Controlled substances, Diabetes, Forensic, Gas chromatography, High performance liquid chromatography, Ion-exchange chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Schizophrenia

Opiate Standards

Over the last decade, the prevalence of nonmedical prescription opioid and opiate use has increased worldwide and is the primary contributor to the global number of drug-related deaths. In the United...
Keywords: Controlled substances, Ion-exchange chromatography

Phenyl-Hexyl Vs Biphenyl Phase for Separation of Pain Management Opiates

Pain management drugs are among the most prescribed medications, and they are also the most abused class of prescription drugs1-2. Therefore, many states have enacted laws governing the prescription ...
Keywords: Chromatography, Clinical, Diffusion, High performance liquid chromatography, Ion Exchange, Liquid chromatography mass spectrometry, Mass spectrometry, Separation

Peer-Reviewed Papers
15

References

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H-005 Hydrocodone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-071 Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®
O-020 Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®
H-008 Hydrocodone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
H-047 Hydrocodone-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
H-048 Hydrocodone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
N-053 Norhydrocodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
N-054 Norhydrocodone-d3 hydrochloride, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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