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L-901 Supelco

Lorazepam solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

  • CAS Number 846-49-1

  • Empirical Formula (Hill Notation) C15H10Cl2N2O2

  • Molecular Weight 321.16

  •  EC Number 200-835-2

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Benzodiazepines, Certified Reference Materials (CRMs),
Quality Level   100
grade   certified reference material
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
drug control   Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
concentration   1.0 mg/mL in acetonitrile
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   −20°C
SMILES string   OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O
InChI   1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChI key   DIWRORZWFLOCLC-UHFFFAOYSA-N
Gene Information   human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Description

General description

A Certified Spiking Solution® suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from clinical toxicology and forensic analysis to urine drug testing. Lorazepam, also known by trade names Ativan® or Orfidal, is a benzodiazepine often prescribed for treatment of anxiety disorders.

Legal Information

Ativan is a registered trademark of American Home Product Corp.

CERILLIANT is a registered trademark of Cerilliant Corporation

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1648 3 / PGII
WGK Germany 
WGK 2
Flash Point(F) 
35.6 °F - closed cup
Flash Point(C) 
2 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Benzodiazepine Standards

Benzodiazepines are a broad class of psychoactive drugs prescribed worldwide for treating numerous conditions from anxiety, seizures, and insomnia to muscle spasms, epilepsy, and alcohol withdrawal.1...
Keywords: Clinical, Forensic, Metabolites, Pharmaceutical

HPLC Analysis of Lorazepam Enantiomers on Astec® (R,R) P-CAP™

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Lorazepam Enantiomers on Astec® (R,R) P-CAP™
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Lorazepam Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Lorazepam Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Lorazepam Enantiomers on Astec® CHIROBIOTIC® TAG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Lorazepam Enantiomers on Astec® CHIROBIOTIC® TAG
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 after Solid Phase Extraction (SPE) using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 after Solid Phase Extraction (SPE) using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion
Keywords: Analgesics, Anticonvulsants, Chromatography, Clinical, Digestions, High performance liquid chromatography, Mass spectrometry, Metabolites, Sample preparations, Solid phase extractions

Medication Monitoring Testing

Prescription monitoring requires accurate reference standards to ensure consistent and reliable results for drug confirmation and monitoring compliance.
Keywords: Anti-depressants, Anticonvulsants, Cardiovascular, Clinical, Controlled substances, Diabetes, Forensic, Gas chromatography, High performance liquid chromatography, Ion-exchange chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Schizophrenia

RP-HPLC Analysis of Benzodiazepines on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents RP-HPLC Analysis of Benzodiazepines on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

UHPLC/MS Analysis of Benzodiazepines and Glucuronide Metabolites on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Benzodiazepines and Glucuronide Metabolites on Titan™ C18
Keywords: High performance liquid chromatography, Mass spectrometry, Metabolites, Separation, Solvents

UHPLC/MS of Drugs and Metabolites in Urine following Enzymatic Hydrolysis

β-D-Glucuronide glucuronosohydrolase enzymes, commonly shortened to β-glucuronidase, play an important role in the analysis of biological fluids for the presence of metabolites for drug screening and...
Craig Aurand, Manager; Kristen Brown, Pennsylvania State University
Reporter US Volume 33.2
Keywords: Carbohydrate metabolism, Derivatizations, Digestions, Enzyme activity, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites, Sample preparations, Separation, Solid phase extractions, Solvents

UHPLC/MS/MS Analysis of Benzodiazepines and Glucuronide Metabolites in Urine on Titan™ C18 after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of Benzodiazepines and Glucuronide Metabolites in Urine on Titan™ C18 after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Sample preparations, Solid phase extractions

Peer-Reviewed Papers
15

References

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D-163 Delorazepam-D4 solution, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®
B-033 Benzodiazepine Multi-component Mixture-8 solution, 250 μg/mL each component in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
L-021 Lorazepam glucuronide solution, 100 μg/mL in acetonitrile: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®
L-902 Lorazepam-d4 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
L-907 Lormetazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
L-911 Lorazepam-d4 solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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