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M-083 Supelco

Methylphenidate hydrochloride solution

(Racemic mixture), ampule of 1 mL, 1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant®

  • CAS Number 298-59-9

  • Empirical Formula (Hill Notation) C14H20ClNO2

  • Molecular Weight 269.77

  •  MDL number MFCD00058191

  •  PubChem Substance ID 329817833

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Properties

Related Categories Additional Standards, Amphetamines / Stimulants Standards, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs),
grade   certified reference material
InChI Key   JUMYIBMBTDDLNG-UHFFFAOYSA-N
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
drug control   Narcotic Licence Schedule A (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)
concentration   1.0 mg/mL in methanol (as free base)
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   2-8°C

Description

General description

Methylphenidate is a psychostimulant prescribed for treatment of attention-deficit hyperactivity disorder (ADHD), tachycardia and narcolepsy. This Certified Spiking Solution® is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology and forensic analysis. Methylphenidate is sold under trade names Concerta® and Ritalin®.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Concerta is a registered trademark of ALZA Corporation

Ritalin is a registered trademark of Novartis Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
48.2 °F
Flash Point(C) 
9 °C

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Amphetamines-weight loss drugs

Sigma-Aldrich's Cerilliant brand provides the widest selection of Certified Spiking Solutions® for amphetamines and weight loss drugs including native and stable-labeled analogs of amphetamine, metha...
Keywords: Ion-exchange chromatography

HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® T2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® T2
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Methylphenidate Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

LC/MS Analysis of Combination Drug Panel in Urine on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Combination Drug Panel in Urine on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

LC/MS Analysis of Combination Drug Panel on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Combination Drug Panel on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Medication Monitoring Testing

Prescription monitoring requires accurate reference standards to ensure consistent and reliable results for drug confirmation and monitoring compliance.
Keywords: Anti-depressants, Anticonvulsants, Cardiovascular, Clinical, Controlled substances, Diabetes, Forensic, Gas chromatography, High performance liquid chromatography, Ion-exchange chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Schizophrenia

Synthesis and Characterization of threo Ritalinic Acid D10 Hydrochloride

As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance. To this end ±-threo-ritalinic acid-D10 HCl (3) was synthesized in seven steps with a purity...
Elizabeth B. Marek PhD, Huahua Jian PhD, Uma Sreenivasan PhD, Isil Dilek, PhD

Keywords: Clinical, Flame ionization detector, Gas chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Nuclear magnetic resonance spectroscopy, Reductions

±threo-Ritalinic acid-D10 Hydrochloride an internal standard for quantitation of Ritalinic acid by LCMSMS: Synthesis determination of isotopic distribution by qNMR and LCMS

As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid2 is of clinical relevance. To this end ±-threo-ritalinic acid-D10HCl3 was synthesized in seven steps with a purity of 99%...
Elizabeth B. Marek, Joshua Cooper, Huahua Jian, Uma Sreenivasan, Isil Dilek

Keywords: Capillary electrophoresis, Clinical, Flame ionization detector, Gas chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Nuclear magnetic resonance spectroscopy, Reductions

Peer-Reviewed Papers
15

References

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D-122 Diethylpropion-D10 hydrochloride solution, 100 μg/mL in methanol (with 1% 1 M HCl, (as free base)), certified reference material, ampule of 1 mL, Cerilliant®
M-127 Methylphenidate-d9 hydrochloride solution, (Racemic mixture of erythro and threo isomers), ampule of 1 mL, 100 μg/mL in methanol (as free base), certified reference material, Cerilliant®
R-011 Ritalinic acid hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
R-014 (±)-threo-Ritalinic acid-d10 hydrochloride, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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