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M-136 Supelco

Methotrexate solution

1.0 mg/mL in methanol with 0.1N NaOH, ampule of 1 mL, certified reference material, Cerilliant®

  • CAS Number 59-05-2

  • Empirical Formula (Hill Notation) C20H22N8O5

  • Molecular Weight 454.44

  •  MDL number MFCD00064369

  •  PubChem Substance ID 329817872

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Properties

Related Categories Additional Drugs, Additional Standards, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs),
grade   certified reference material
InChI Key   FBOZXECLQNJBKD-UHFFFAOYSA-N
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   1.0 mg/mL in methanol with 0.1N NaOH
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   −20°C

Description

General description

A Certified Spiking Solution® for use in therapeutic drug monitoring (TDM) analyses by HPLC or LC/MS. Used in the treatment of cancer and autoimmune diseases, methotrexate is an antimetabolite and antifolate drug monitored by clinical labs to ensure patients remain within the drug’s therapeutic range. The Snap-N-Spike® format allows laboratories to eliminate weighing operations of hazardous substances such as methotrexate, significantly reducing occupational exposure hazards related to handling of acutely toxic powders, and provides the ability to spike into their matrix of choice just before use.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
51.8 °F
Flash Point(C) 
11 °C

Documents

Certificate of Analysis

Protocols & Articles

Articles

HPLC Analysis of Aminopterin and Related Compounds on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Aminopterin and Related Compounds on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Aminopterin and Related Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Aminopterin and Related Compounds on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antineoplastic Drugs on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antineoplastic Drugs on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antineoplastic Drugs on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antineoplastic Drugs on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Therapeutic Drug Monitoring Standards

Therapeutic drug monitoring (TDM) measures drug concentrations in blood and other biological fluids to ensure maintenance of a drug’s therapeutic range. TDM is performed routinely to guide the dosing...
Keywords: Anti-depressants, Anticonvulsants, Antifungals, Cancer, High performance liquid chromatography, Immunoassay, Ion-exchange chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Peer-Reviewed Papers
15

References

Related Products

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M-153 Methotrexate-D3 solution, 100 μg/mL in methanol with 0.01N NaOH, ampule of 1 mL, certified reference material, Cerilliant®
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