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Ritalinic acid hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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Properties

Related Categories Additional Standards, Amphetamines, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs),
Quality Level   100
grade   certified reference material
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   1.0 mg/mL in methanol (as free base)
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   −20°C
SMILES string   Cl.OC(=O)C(C1CCCCN1)c2ccccc2
InChI   1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
InChI key   SCUMDQFFZZGUQY-UHFFFAOYSA-N

Description

General description

Ritalin®ic acid is a primary blood metabolite of methylphenidate, a psychostimulant sold under trade names Concerta® and Ritalin®. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis. Methylphenidate is prescribed for treatment of attention-deficit hyperactivity disorder (ADHD), tachycardia, and narcolepsy.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

Concerta is a registered trademark of ALZA Corporation

Ritalin is a registered trademark of Novartis Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Eyes
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
WGK 1
Flash Point(F) 
49.5 °F - closed cup
Flash Point(C) 
9.7 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

LC/MS Analysis of Combination Drug Panel in Urine on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Combination Drug Panel in Urine on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

LC/MS Analysis of Combination Drug Panel on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Combination Drug Panel on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Synthesis and Characterization of threo Ritalinic Acid D10 Hydrochloride

As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance. To this end ±-threo-ritalinic acid-D10 HCl (3) was synthesized in seven steps with a purity...
Elizabeth B. Marek PhD, Huahua Jian PhD, Uma Sreenivasan PhD, Isil Dilek, PhD

Keywords: Clinical, Flame ionization detector, Gas chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Nuclear magnetic resonance spectroscopy, Reductions

±threo-Ritalinic acid-D10 Hydrochloride an internal standard for quantitation of Ritalinic acid by LCMSMS: Synthesis determination of isotopic distribution by qNMR and LCMS

As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid2 is of clinical relevance. To this end ±-threo-ritalinic acid-D10HCl3 was synthesized in seven steps with a purity of 99%...
Elizabeth B. Marek, Joshua Cooper, Huahua Jian, Uma Sreenivasan, Isil Dilek

Keywords: Capillary electrophoresis, Clinical, Flame ionization detector, Gas chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Nuclear magnetic resonance spectroscopy, Reductions

Peer-Reviewed Papers
15

References

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M-083 Methylphenidate hydrochloride solution, (Racemic mixture), ampule of 1 mL, 1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant®
M-127 Methylphenidate-d9 hydrochloride solution, ampule of 1 mL, (Racemic mixture of erythro and threo isomers), 100 μg/mL in methanol (as free base), certified reference material, Cerilliant®
R-014 (±)-threo-Ritalinic acid-d10 hydrochloride, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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