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(±)-threo-Ritalinic acid-d10 hydrochloride

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym: (±)-threo-Ritalinic acid-d10 HCl solution

  • Empirical Formula (Hill Notation) C13H7NO2D10

  • Molecular Weight 229.34

  •  EC Number 200-659-6

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Amphetamines, Analytical Standards, Analytical/Chromatography, Certified Reference Materials (CRMs),
Quality Level   100
grade   certified reference material
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   100 μg/mL in methanol (as free base)
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
storage temp.   −20°C
SMILES string   Cl.[2H]C1([2H])N[C@@]([2H])(C([2H])([2H])C([2H])([2H])C1([2H])[2H])[C@]([2H])(C(O)=O)c2ccccc2
InChI   1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H/t11-,12+;/m0./s1/i4D2,5D2,8D2,9D2,11D,12D;
InChI key   SCUMDQFFZZGUQY-SMKJLJITSA-N

Description

General description

Ritalinic acid is the major urinary metabolite of methylphenidate, more commonly known by the brand name Ritalin® which is approved for treatment of ADHD (Attention-Deficit Hyperactivity Disorder) and narcolepsy. This new stable-labeled internal standard is suitable for a wide variety of GC/MS and LC/MS applications from clinical toxicology and urine drug testing to forensic analysis and isotope dilution methods.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

Ritalin is a registered trademark of Novartis Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Eyes
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
WGK 1
Flash Point(F) 
49.5 °F - closed cup
Flash Point(C) 
9.7 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Synthesis and Characterization of threo Ritalinic Acid D10 Hydrochloride

As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance. To this end ±-threo-ritalinic acid-D10 HCl (3) was synthesized in seven steps with a purity...
Elizabeth B. Marek PhD, Huahua Jian PhD, Uma Sreenivasan PhD, Isil Dilek, PhD

Keywords: Clinical, Flame ionization detector, Gas chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Nuclear magnetic resonance spectroscopy, Reductions

±threo-Ritalinic acid-D10 Hydrochloride an internal standard for quantitation of Ritalinic acid by LCMSMS: Synthesis determination of isotopic distribution by qNMR and LCMS

As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid2 is of clinical relevance. To this end ±-threo-ritalinic acid-D10HCl3 was synthesized in seven steps with a purity of 99%...
Elizabeth B. Marek, Joshua Cooper, Huahua Jian, Uma Sreenivasan, Isil Dilek

Keywords: Capillary electrophoresis, Clinical, Flame ionization detector, Gas chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Nuclear magnetic resonance spectroscopy, Reductions

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M-083 Methylphenidate hydrochloride solution, (Racemic mixture), ampule of 1 mL, 1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant®
M-127 Methylphenidate-d9 hydrochloride solution, ampule of 1 mL, (Racemic mixture of erythro and threo isomers), 100 μg/mL in methanol (as free base), certified reference material, Cerilliant®
R-011 Ritalinic acid hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
06693 Timestrip Plus -20 °C

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