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  • 04-145 - Anti-NOD2 Antibody, clone 2D9

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04-145 Sigma-Aldrich

Anti-NOD2 Antibody, clone 2D9

clone 2D9, from mouse

Synonym: Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NLR family, CARD domain containing 2, NOD-like receptor C2, caspase recruitment domain family, member 15, caspase recruitment domain protein 15, nucleotide-binding ol

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, NK-NR, Primary Antibodies
clone   2D9, monoclonal
biological source   mouse
application(s)   immunohistochemistry: suitable
  immunoprecipitation (IP): suitable
  western blot: suitable
species reactivity   human, human, human, human
shipped in   wet ice
isotype   IgG1κ
Quality Level   100
antibody product type   primary antibodies
NCBI accession no.   NP_071445
UniProt accession no.   Q9HC29
Gene Information   human ... NOD2(64127)

Description

General description

NOD2 (nucleotide-binding oligomerization domain containing 2), also known as the caspase recruitment domain family, member 15 (CARD15), is a member of the NOD-like Receptor (NLR) family of proteins and plays an important role in the immune system. It is an intracellular pattern recognition receptor and is linked to inflammatory diseases such as inflammatory bowel disease/Crohn′s Disease and Blau syndrome. NOD2 has two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules. Recently it is has been found to interact with NLRC4 and bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response.

Specificity

This antibody recognizes NOD2.

Immunogen

Epitope: Unknown

His-tagged recombinant protein corresponding to human NOD2.

Application

Anti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP.

Research Category
Inflammation & Immunology

Research Sub Category
Immunological Signaling

Target description

~110 kDa

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected NOD2 in hyperplastic colorectal carcinoma tissue.

Analysis Note

Control
Hyperplastic colorectal carcinoma tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Articles

Antibody Basics

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