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04-1579 Sigma-Aldrich

Anti-Interleukin-13 (IL-13) Antibody, clone B2

Detect Interleukin-13 (IL-13) using this Anti-Interleukin-13 (IL-13) Antibody, clone B2 validated for use in WB.

Synonym: interleukin 13, interleukin-13

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
gene symbol   ALRH(260328)
  IL13(3596)
  BHR1
  IL-13
  NC30
  P600
NCBI accession no.   NP_002179
UniProt accession no.   P35225
Quality Assurance   Evaluated by Western Blot in lysates from cells expressing human IL-13 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-13 recombinant protein.
application(s)   Western Blotting
clone   AB31.56.13G1.B2
  Monoclonal Antibody
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
format   Purified
host   Mouse
isotype   IgG1κ
molecular weight   ~13 kDa observed
packaging   100 µg (04-1579)
shipped in   wet ice
species reactivity   Human

Description

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Analysis Note

Control
Human IL-13 recombinant protein

Application

ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX).

Research Category
Inflammation & Immunology

Research Sub Category
Cytokines & Cytokine Receptors

General description

Interleukin-13 (IL-13) is a cytokine that is secreted by helper T cells in reaction to T cell antigen receptor signaling. IL-13 is also secreted by mast cells and basophils when cross-linking with immunoglobulin E. IL-13 seems to play a role as an effector in ulcerative colitis that weakens epithelial barrier function by influencing epithelial apoptosis, tight junctions and restitution velocity. IL-13 has been shown to be involved in the pathogenesis of allergic diseases such as atopic dermatitis. IL-13 seems to also have a role to play in alcohol mediated activation of pro-fibrotic pathways. IL-13 is thought to be an important cytokine during the expansion of asthma and chronic obstructive pulmonary disease and may be critical clinical therapy targets.

Immunogen

Full-length recombinant protein corresponding to human IL-13.

Physical form

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Peer-Reviewed Papers
15

References

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