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05-1115 Sigma-Aldrich

Anti-SG2NA Antibody

Anti-SG2NA Antibody is an antibody against SG2NA for use in WB, IC & IP.

Synonym: Cell-cycle autoantigen SG2NA, Striatin 3

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Primary Antibodies, SG-SK
clone   monoclonal
biological source   mouse
application(s)   immunocytochemistry: suitable
  immunoprecipitation (IP): suitable
  western blot: suitable
species reactivity   rat, mouse, human
shipped in   wet ice
antibody form   ascites fluid
isotype   IgG1
Quality Level   100
antibody product type   primary antibodies
NCBI accession no.   NM_001083893.1
UniProt accession no.   Q13033
Gene Information   human ... STRN3(29966)

Description

General description

SG2NA, also known as Striatin 3, was identified as a human cancer auto-antigen and has not been implicated in vesicular trafficking and signal tranduction. It is highly related to striatin and zinedin (striatin 4). It is a cytoplasmic scaffolding protein that binds to Calmodulin and PP2A A and C subunits as well as the human homolog of the yeast protein, Mob1, which appears to modulate PP2A activity.

Specificity

Reacts with SG2NA. No cross reactivity with striatin.

Immunogen

Synthetic peptide from SG2NA.

Application

Immunocytochemistry: A previous lot of this antibody was used in immunocytochemistry at a 1:500 dilution.

Immunoprecipitation: A previous lot of this antibody was used in IP; 3 μL is a recommended as starting point for immunoprecipitation.
Optimal working dilutions must be determined by end user.

Research Category
Signaling

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Target description

The antibody recognizes the ~93 kDa SG2NA protein in Jurkat cell lysate. In some cell types a band of ~70 kDa is also recognized, which may be an alternatively spliced form of SG2NA or another unknown protein.

Physical form

Mouse monoclonal IgG1 ascites containing 40% glycerol and 0.02% sodium azide.

Storage and Stability

Stable at -20°C in undiluted aliquots for up to 1 year from date of receipt. For long-term storage, may be stored at -80°C.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality

Routinely evaluated by Western Blot on L6 lysates.

Western Blot Analysis: 1:500 dilution of this lot detected SG2NA on 10 μg of L6 lysates.

Linkage

Replaces: MAB5464

Analysis Note

Control
L6 cell lysate

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Articles

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