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05-23-3801 Sigma-Aldrich

Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem

Attenuates thrombin-evoked aggregation of human platelets.

Synonym: ET-3, CTCFTYKDKECVYYCHLDIIW, Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem

  • CAS Number 117399-93-6

  • Empirical Formula (Hill Notation) C121H168N26O33S4

  • Molecular Weight 2643.04

  •  MDL number MFCD00076378

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Properties

Quality Level   100
assay   ≥97% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
solubility   5% acetic acid: 0.5 mg/mL
shipped in   ambient

Description

General description

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ETA receptors.

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Stimulator of interleukin-6 production by endothelial cell lines

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Sequence

H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

Physical form

Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.

Preparation Note

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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