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  • 05-824 - Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal

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05-824 Sigma-Aldrich

Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal

Detect Estrogen Receptor β also known as Nuclear receptor subfamily 3 group A member 2 with Anti-Estrogen Receptor β Antibody, clone 68-4 (Rabbit Monoclonal Antibody), that has been demonstrated to work in IP & WB.

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   100 µL (05-824-25UL)
  25 µL (05-824-25UL)
application(s)   immunoprecipitation (IP): suitable
  western blot: suitable
biological source   rabbit
clone   68-4, monoclonal
isotype   IgG
shipped in   ambient
species reactivity   , human
gene symbol   ESR2(2100)
trade name   Upstate
brand family   Upstate
format   Purified
molecular weight   59 kDa
clone   Monoclonal Antibody
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
Species Reactivity Notes   Predicted to cross-react with rat and mouse based on sequence homology
gene symbol   ER-BETA
  ER-beta
  ESR-BETA
  ESRB
  ESTRB
  Erb
  NR3A2
Quality Assurance   routinely evaluated by immunoblot on RIPA lysates from MCF7 cells

Description

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Target description

59 kDa

Analysis Note

Control
MCF7 cell extracts

Application

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

General description

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.

Produced in collaboration with Epitomics

Immunogen

KLH-conjugated linear peptide corresponding to amino acids 108-127 from the N-terminal half of human estrogen receptor beta.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Specificity

Recognizes Estrogen Receptor β, long form, does not detect estrogen receptor alpha.

Physical form

Format: Purified

Protein A Purfied

Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% sodium azide, pH 7.4.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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Technical Service:

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