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06-1038 Sigma-Aldrich

Anti-Unc84B/SUN2 Antibody

This Anti-Unc84B/SUN2 Antibody is validated for use in Immunoprecipitation and Western Blotting for the detection of Unc84B/SUN2.

Synonym: Rab5-interacting protein, Sad1 unc-84 domain protein 2, Sad1/unc-84 protein-like 2, nuclear envelope protein, unc-84 homolog B, unc-84 homolog B (C. elegans)

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   100 µg (06-1038)
isotype   IgG
gene symbol   SUN2(25777)
format   Affinity Purified
molecular weight   ~80 kDa
application(s)   Immunoprecipitation
  Western Blotting
clone   Polyclonal Antibody
concentration   0.5 mg/mL
host   Rabbit
species reactivity   Canine
  Horse
  Human
Species Reactivity Notes   Proven to react with human. Predicted to react with dog and horse based on sequence homology. Mouse and rat (87%).
NCBI accession no.   NP_056189
UniProt accession no.   Q9UH99
gene symbol   FRIGG
  RAB5IP
  Rab5IP
  UNC84B
shipped in   wet ice
Quality Assurance   Evaluated by Western Blotting in U2OS cell lysate.

Western Blot (SNAP ID) Analysis: 1:250 dilution of this antibody detected Unc84B/SUN2 on 10 µg of U2OS cell lysate.

Description

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Analysis Note

Control
U2OS cell lysate.

Application

Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated Unc84B/SUN2 from 500 µg of U2OS cell lysate.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

General description

UNC84B (Protein UNC-84 homolog B or SUN2), is a single-pass nuclear envelope transmembrane protein responsible for nuclear migrations that are essential for development. UNC-84B has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1. UNC-84B interacts with RAB5A and is widely expressed, and highly expressed in the heart, lungs and muscles. UNC-84 may function to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.

Immunogen

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to human Unc84B/SUN2 at and around the N-terminus.

Specificity

This antibody recognizes Unc84B/SUN2 at the N-terminus.

Physical form

Affinity Purfied

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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