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06-138 Sigma-Aldrich

Anti-Cyclin A Antibody

  •  eCl@ss 32160702

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, CT-CZ, Primary Antibodies
clone   polyclonal
biological source   rabbit
application(s)   immunocytochemistry: suitable
  immunoprecipitation (IP): suitable
  western blot: suitable
species reactivity   human, sheep, mouse, rat
shipped in   dry ice
isotype   IgG
antibody product type   primary antibodies
mfr. no.   Upstate®
NCBI accession no.   NM_001237
UniProt accession no.   P20248
Gene Information   human ... CCNA2(890)

Description

General description

The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.

Specificity

p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3

Immunogen

peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)

Application

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Target description

58kDa

Physical form

Format: Purified

Lyophilized

Protein G Chromatography

Storage and Stability

2 years at -20°C

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality

routinely evaluated by immunoblot on HeLa nuclear extract

Analysis Note

Control
Daudi cells

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
15

References

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