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06-520 Sigma-Aldrich

Anti-Na+/K+ ATPase α-1 Antibody

This Anti-Na+/K+ ATPase α-1 Antibody is validated for use in IC, IP, WB for the detection of Na+/K+ ATPase α-1.

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   100 µg (06-520-25UG)
  25 μg (06-520-25UG)
application(s)   immunocytochemistry: suitable
  immunoprecipitation (IP): suitable
  western blot: suitable
biological source   rabbit
clone   polyclonal
isotype   IgG
mfr. no.   Upstate
shipped in   ambient
species reactivity   rat, human, bovine,
gene symbol   ATP1A1(476)
Species Reactivity Notes   Rat and Human. Expected to cross-react with Rat-100%, Mouse-99%; human, pig, rabbit, monkey-96%.
gene symbol   +K
  G00-119-711
  MGC3285
  MGC51750
  Na

Description

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Target description

112 kDa

Analysis Note

Control
Rat Brain Microsomal Prep. lysate.

Application

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

General description

Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html)

Immunogen

Epitope: Cytoplasmic domain

GST-tagged ATPase.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Routinely evaluated by Immunoprecipitation on rat brain microsomal prep. lysate.

Specificity

Recognizes the α-1 subunit isoform of Na+/K+ ATPase.

Physical form

Format: Purified

Protein A Purfied

Purified antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl and 0.05% NaN3.

Storage and Stability

Stable for 1 year at 2-8ºC from date of receipt.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Making Headway
Protocols & Articles
Peer-Reviewed Papers
15

References

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Technical Service:

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