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06-984 Sigma-Aldrich

Anti-Mn-SOD Antibody

Anti-Mn-SOD Antibody is an antibody against Mn-SOD for use in IH, IH(P) & WB.

Synonym: Mn superoxide dismutase, indophenoloxidase B, manganese superoxide dismutase, manganese-containing superoxide dismutase, mangano-superoxide dismutase, superoxide dismutase 2, mitochondrial

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   200 µg (06-984-25UG)
  25 μg (06-984-25UG)
isotype   IgG
should not react with   canine
gene symbol   SOD2(6648)
trade name   Upstate
brand family   Upstate
format   Purified
molecular weight   ~24 kDa
application(s)   Immunohistochemistry (Paraffin)
  Immunohistochemistry
  Western Blotting
clone   Polyclonal Antibody
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
host   Rabbit
species reactivity   Bovine
  Human
  Mouse
  Rat
NCBI accession no.   NP_000627
UniProt accession no.   P04179
gene symbol   IPO-B
  MNSOD
  Mn-SOD
  MnSOD
shipped in   ambient
Quality Assurance   Evaluated by western blot on RIPA lysates of MCF-7, A431 or rat L6 RIPA cells.

Western Blot Analysis:
0.5-2 μg/mL of this antibody detected MnSOD in RIPA lysates of rat L6 RIPA cells. 1-4 μg/mL of a previous lot detected MnSOD in RIPA lysates of human MCF-7, A431 and rat L6 RIPA cells.

Description

Analysis Note

Control
L6 cell lysate, rat brain tissue extract.

Application

Immunohistochemistry (Paraffin):
10 μg/mL of a previous lot detected MnSOD in paraffin embedded rat brain tissue sections.

General description

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn SOD/SOD1), mitochondrial manganese SOD (Mn SOD/SOD2) and extracellular Cu, Zn SOD (EC SOD/SOD3). The manganese containing 80 kDa tetrameric enzyme SOD2 is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain.

Immunogen

Recombinant human MnSOD (manganous superoxide dismutase).

Specificity

Recognizes MnSOD, Mr 24 kDa.

Physical form

Purified rabbit polyclonal in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Making Headway
Protocols & Articles

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Peer-Reviewed Papers
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References

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