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  • 09-071 - Anti-G9a (BAT8) Antibody

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09-071 Sigma-Aldrich

Anti-G9a (BAT8) Antibody

Anti-G9a (BAT8) Antibody is a rabbit polyclonal antibody for detection of G9a (BAT8) also known as G9A histone methyltransferase ,H3-K9-HMTase 3 ,HLA-B associated transcript 8 & has been validated in WB.

Synonym: G9A histone methyltransferase, H3-K9-HMTase 3, HLA-B associated transcript 8, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, Lysine N-methyltransferase 1C, Protein G9a, ankyrin repeat-containing protein, chromosome 6 open reading frame

  •  eCl@ss 32160702

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Properties

Related Categories Antibodies, Primary Antibodies More...
packaging   100 µg (09-071)
biological source   rabbit
format   Affinity Purified
molecular weight   ~160 kDa
application(s)   Western Blotting
clone   Polyclonal Antibody
concentration   Please refer to the Certificate of Analysis for the lot-specific concentration.
species reactivity   Canine
  Human
  Mouse
  Rat
Species Reactivity Notes   Proven to react with human and mouse. Predicted to react with rat and canine based on sequence homology.
NCBI accession no.   NP_006700.3
UniProt accession no.   Q96KQ7
gene symbol   BAT8
  C6orf30
  DKFZp686H08213
  EC 2.1.1.43
  Em:AF134726.3
  FLJ35547
  G9A
  KMT1C
  NG36/G9a
  NG36
  OTTHUMP00000029262
shipped in   wet ice
Quality Assurance   Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: : 0.25-2 µg/mL of this antibody detected G9a (BAT8) in 10 µg of HeLa cell lysate.

Description

Application

Western Blot Analysis (SNAP ID Technique): 1 µg/mL from a previous lot detected G9a (BAT8) on 10 µg of HeLa cell lysate.

General description

G9a (BAT8 or Histone-lysine N-methyltransferase) is thought to be involved in intracellular protein-protein interaction and is a lysine-preferring histone methyltransferase. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. The presence of the ankyrin repeats also suggests that G9a is involved in intracellular protein-protein interaction. Like Suv39h1, G9a transfers methyl groups to the lysine residues of histone H3, but with a 10- to 20-fold higher activity. G9a is localized to the nucleus but not in the repressive chromatin domains of centromeric loci, in which Suv39h1 family proteins were localized. This protein is probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. G9a also methylates histone H1.

Immunogen

KLH-conjugated linear peptide corresponding to G9a (BAT8).

Specificity

This antibody recognizes G9a (BAT8).

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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