• USA Home
  • 100065 - 2-APB - CAS 524-95-8 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
100065 Sigma-Aldrich

2-APB - CAS 524-95-8 - Calbiochem

A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.

Synonym: 2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane, 2-APB - CAS 524-95-8 - Calbiochem

  • CAS Number 524-95-8

  • Empirical Formula (Hill Notation) C14H16BNO

  • Molecular Weight 225.09

  •  NACRES NA.77

Purchase

Properties

assay   ≥97% (titration)
form   crystalline solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +2C to +8C
color   white
solubility   DMSO: 20 mg/mL
  95% ethanol: 25 mg/mL
shipped in   ambient

Description

General description

A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles.

A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.

Packaging

100 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Ins(1,4,5)P3-induced Ca2+ release

Product does not compete with ATP.

Reversible: no

Target IC50: 42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Brooke, R. T., et al. 2004. Lab. Invest.84, 29.
Gregory, R.B., et al. 2001. Biochem. J.354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun.264, 979.
Maruyama, T., et al. 1997. J. Biochem.122, 498.

Safety & Documentation

Safety Information

RTECS 
ED6150000

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?