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1.00130 SAFC

Benzoic acid

powder, EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 210

Synonym: Benzoic acid, Phenylformic acid, Benzene carboxylic acid

  • CAS Number 65-85-0

  • Empirical Formula (Hill Notation) C7H6O2

  • Molecular Weight 122.12

  •  E Number E210

  •  EC Index Number 200-618-2

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Properties

Related Categories APIs (Active Pharmaceutical Ingredients) and Excipients, Acidulents & pH Adjusters, Biopharmaceutical Process Development and Manufacturing, Excipients, Liquid Dosage Forms,
Agency/Method   BP
  Ph. Eur.
  USP
Quality Level   500
vapor pressure   0.001 hPa ( 20 °C)
product line   Emprove® Essential
assay   99.5-100.5% substance (anhydrous) basis (acidimetric)
form   solid
autoignition temp.   570 °C
potency   1700 mg/kg LD50, oral (Rat)
  >5000 mg/kg LD50, skin (Rabbit)
pH   2.5-3.5 (20 °C in H2O, saturated solution)
bp   249 °C/1013 hPa
mp   121-123 °C
transition temp   flash point 121 °C
solubility   water: 2.9 g/L at 25 °C
density   1.321 g/cm3 at 20 °C
bulk density   500 kg/m3
anion traces   sulfate (SO42-): ≤0.02%
cation traces   As: ≤1 ppm
  Cd: ≤10 ppm
  Cr: ≤2.5 ppm
  Cu: ≤10 ppm
  Hg: ≤1 ppm
  Mn: ≤25 ppm
  Ni: ≤2 ppm
  Pb: ≤2 ppm
  Zn: ≤10 ppm
InChI   1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)
InChI key   WPYMKLBDIGXBTP-UHFFFAOYSA-N
storage conditions   Store at +5°C to +30°C.

Description

General description

powder, EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 210

Application

The specification of the product is part of the Emprove® Material Qualification Dossier and can be found under "General Properties".

Analysis Note

Assay (acidimetric)99.5 - 100.5 %Assay (acidimetric, calc. on anhydrous substance)99.5 - 100.5 %IdentityconformsAppearance of solution (5 %; ethanol 96 %)passes testpH-value (saturated solution)2.5 - 3.5Solidification point (lower value)≥ 121 °CSolidification point (upper value)≤ 123 °CSulfate (SO₄)≤ 0.02 %As (Arsenic)≤ 1 ppmCd (Cadmium)≤ 10 ppmCr (Chromium)*≤ 2.5 ppmCu (Copper)*≤ 10 ppmHg (Mercury)≤ 1 ppmMn (Manganese)*≤ 25 ppmNi (Nickel)*≤ 2 ppmPb (Lead)≤ 2 ppmZn (Zinc)*≤ 10 ppmHalogenated compounds (as Cl)≤ 0.01 %Toluene (HS-GC)≤ 890 ppmOther residual solvents (ICH Q3C)excluded by the production prozessOxidizable matter (Ph Eur)passes testOxidizable matter (USP)passes testReadily carbonisable substancepasses testWater≤ 0.5 %Sulfated ash≤ 0.05 %Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Conforms to the purity criteria on food additives according to the current European Commission Regulation.Corresponds to Ph Eur, BP, USP, E 210

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

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