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1.02425 SAFC

Chloral hydrate

EMPROVE® ESSENTIAL Ph Eur,BP,JP,USP

Synonym: Chloral hydrate, Trichloroacetaldehyde hydrate

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Properties

Agency/Method   BP
  JP
  Ph Eur
  USP
Quality Level   500
vapor pressure   13 hPa ( 20 °C)
product line   Emprove® Essential
potency   479 mg/kg LD50, oral (Rat)
  3030 mg/kg LD50, skin (Rat)
pH   3.5-5.5 (20 °C, 100 g/L in H2O)
bp   97 °C/1013 hPa (decomposes)
mp   52 °C
solubility   6600 g/L
density   1.91 g/cm3 at 20 °C
InChI   1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H
InChI key   RNFNDJAIBTYOQL-UHFFFAOYSA-N
storage conditions   Store at +15°C to +25°C.

Description

General description

EMPROVE® ESSENTIAL Ph Eur,BP,JP,USP

Analysis Note

Assay (alkalimetric)99.5 - 101.0 %Identitypasses testAppearance of solution (Ph Eur)passes testAppearance of solution (JP)passes testAcidic substancespasses testpH-value (10 %; water)3.5 - 5.5Chloride (Cl)≤ 0.007 %Heavy metals (as Pb)≤ 0.0020 %Chloral alcoholatepasses testBenzenepasses testToluene≤ 890 ppmOther residual solvents (ICH Q3C)excluded by production processSubstances discolored by H₂SO₄passes testNon volatile matter≤ 0.1 %Sulfated ash≤ 0.10 %Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).Corresponds to Ph Eur, BP, JP

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

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