EMAIL THIS PAGE TO A FRIEND
1.03000 SAFC

Triacetin

EMPROVE® ESSENTIAL Ph Eur,BP,USP

Synonym: Triacetin

  • CAS Number 102-76-1

  • Empirical Formula (Hill Notation) C9H14O6

  • Molecular Weight 218.20

  •  MDL number MFCD00008716

  •  EC Index Number 203-051-9

Purchase

Properties

Related Categories APIs (Active Pharmaceutical Ingredients) and Excipients, Biopharmaceutical Process Development and Manufacturing, Coatings & Supporting Materials, Excipients, Liquid Dosage Forms,
Agency/Method   BP
  Ph. Eur.
  USP
Quality Level   500
vapor pressure   <0.1 hPa ( 20 °C)
product line   Emprove® Essential
form   liquid
autoignition temp.   430 °C
potency   3000 mg/kg LD50, oral (Rat)
  >5000 mg/kg LD50, skin (Rabbit)
expl. lim.   1.1-7.7 % (v/v)
pH   5.0-6.0 (20 °C, 50 g/L in H2O)
bp   258 °C/1013 hPa
mp   -78 °C
transition temp   flash point 138 °C
solubility   64 g/L
density   1.16 g/cm3 at 20 °C
InChI   1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3
InChI key   URAYPUMNDPQOKB-UHFFFAOYSA-N
storage conditions   Store at +15°C to +25°C.

Description

Application

The specification of the product is part of the Emprove® Material Qualification Dossier and can be found under "General Properties".

Analysis Note

Assay (alkalimetric, calculated on anhydrous substance): 98.5 - 100.5 %
Assay (GC, calc. on anhydrous substance): 97.0 - 102.0 %
Identity (IR-spectrum): passes test
Identity (GC): passes test
Appearance: clear colorless, slightly viscous liquid, not more intense in color than reference solution Y₆
Acidity (Ph Eur/ USP): passes test
Refractive index (n 20/D): 1.430 - 1.432
Density (d 20/20): 1.159 - 1.164
As (Arsenic)*: ≤ 1.5 ppm
Acetic acid (GC): ≤ 0.1 %
Glycerol (GC): ≤ 0.1 %
1-Monoacetin (GC): ≤ 0.1 %
2-Monoacetin (GC): ≤ 0.1 %
1,3-Diacetin (GC): ≤ 0.1 %
1,2-Diacetin (GC): ≤ 0.1 %
Individual, unspecified impurity (GC): ≤ 0.1 %
Sum of all impurities (GC): ≤ 0.2 %
Acetic Acid (Acidity): ≤ 5000 ppm
Butylacetate (HS-GC): ≤ 5000 ppm
Other residual solvents (ICH Q3C): excluded by manufacturing process
Water (according to Karl Fischer): ≤ 0.2 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., BP, USP

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Emprove® Dossiers

Already an EMPROVE® Program customer? Sign in to access your EMPROVE® Dossiers

Sign In
What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Three document types are included with an Emprove® Program subscription:

  • Material Qualification Dossiers
  • Quality Management Dossiers
  • Operational Excellence Dossiers

Learn more about the benefits an Emprove® Program subscription can provide

Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?