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1.06018 Supelco

Methanol

for liquid chromatography LiChrosolv®

Synonym: Methyl alcohol

  • CAS Number 67-56-1

  • Linear Formula CH3OH

  • Molecular Weight 32.04

  •  Beilstein/REAXYS Number 1098229

  •  MDL number MFCD00004595

  •  EC Index Number 200-659-6

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Properties

Related Categories HPLC Grade Solvents, HPLC Solvents, Solvent by Application, Solvents
Quality Level   100
vapor density   1.11 (vs air)
vapor pressure   128 hPa ( 20 °C)
  410 mmHg ( 50 °C)
  97.68 mmHg ( 20 °C)
assay   ≥99.8% (GC)
form   liquid
autoignition temp.   725 °F
potency   5628 mg/kg LD50, oral (Rat)
  17100 mg/kg LD50, skin (Rabbit)
expl. lim.   36 %
application(s)   LC/MS: suitable
refractive index   n20/D 1.329 (lit.)
kinematic viscosity   0.54-0.59 cSt(20 °C)
bp   64.7 °C (lit.)
mp   −98 °C (lit.)
transition temp   flash point 9.7 °C
density   0.791 g/mL at 25 °C (lit.)
SMILES string   CO
InChI   1S/CH4O/c1-2/h2H,1H3
InChI key   OKKJLVBELUTLKV-UHFFFAOYSA-N
storage conditions   Store at +5°C to +30°C.

Description

General description

With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in "gradient grade" as well as "isocratic grade". This enables to minimize the gradient effect of the solvent involved.

Analysis Note

Evaporation Number: 1.9

Purity (GC): ≥ 99.8 %
Identity (IR): conforms
Evaporation residue: ≤ 3.0 mg/l
Water: ≤ 0.03 %
Color: ≤ 10 Hazen
Acidity: ≤ 0.0002 meq/g
Alkalinity: ≤ 0.0002 meq/g
Transmission (at 225 nm): ≥ 50 %
Transmission (at 240 nm): ≥ 80 %
Transmission (from 265 nm): ≥ 98 %
Filtered by 0.2 µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Eyes
WGK Germany 
WGK 2
Flash Point(F) 
51.8 °F - closed cup
Flash Point(C) 
11.0 °C - closed cup
Protocols & Articles

Articles

Miconazole USP Method for organic Impurities Using HPTLC Plates

Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections.
Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Antifungals, Solvents, Thin layer chromatography

Authenticity of Essential Oils: A HPTLC Fingerprint Method

Due to the increasing popularity of natural essential oils as products for personal care, pharmaceuticals, or for aromatherapy, the global market for essential oils is growing rapidly.1 Unfortunately...
Keywords: Addition reactions, Chromatography, Degradations, Derivatizations, Detection methods, Flame ionization detector, Gas chromatography, Nuclear magnetic resonance spectroscopy, Pharmaceutical, Solvents, Thin layer chromatography

Bisoprol Fumarate and Hydrochlorothiazide

Bisoprolol Fumarate is used in the treatment of high blood pressure (hypertension), and it reduce blood flow. Thus a preventive treatment before and after heart attacks, decreasing the chances of rec...
Dr. Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Diuretics, Indicators, Solvents, Thin layer chromatography

Determination of Caffeine in Coffee using High Performance Thin Layer Chromatography

High Performance Thin Layer Chromatography (HPTLC) is a very useful analytical technique and requires low sample preparation, here illustrated through the analysis of caffeine in coffee. Only extract...
Keywords: Chromatography, Filtration, Gas chromatography, Gene expression, High performance liquid chromatography, Mass spectrometry, Planar chromatography, Sample preparations, Separation, Thin layer chromatography

Determination of Vitamin A and E Using HPLC with UV Detection Following the Chinese National Standard (GB) Method

Following GB method for Vitamin A and Vitamin E as it is written with a 250 x 4.6 mm Ascentis® Express C30 column gives baseline resolution between the critical pair (gamma-, and beta-tocopherol; pea...
Keywords: Separation, Vitamins

European Pharmacopoeia Method for Diclofenac Identification Test B using Silica Gel G TLC plates

Diclofenac sodium is a non-steroidal anti-inflammatory (NSAID) drug. It is used to treat pain, inflammatory disorders, and dysmenorrhea.
Dr. Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Anti-inflammatory agents, Indicators, Thin layer chromatography

European Pharmacopoeia Method for Timolol Identification Test C using silica gel G TLC plates

Timolol is a medication used either by mouth or as eye drops. As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma.
Dr Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Indicators, Thin layer chromatography

Lopinavir and Ritonavir Tablets Assay Method Following United States Pharmacopeia Monograph Guidelines Using an Ascentis C8 Column and UV Detection

This application note illustrates how it is possible to set-up an assay method for Lopinavir and Ritonavir tablets. The given experimental conditions follow the current USP43-NF38 monograph; the chro...
Keywords: High performance liquid chromatography

Oxymetazoline Hydrochloride Identification Test B using silica gel G TLC plates

Oxymetazoline is an adrenergic alpha-agonists, used as a vasoconstrictor to relieve nasal congestion.

Keywords: Solvents, Thin layer chromatography

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Qualitative Thin Layer Chromatography Analysis of Flavonoids and Quantification of Terpene Lactones in Ginkgo Biloba Extracts and Tablets

Ginkgo is one of the oldest medicinal plants on earth. Originally it comes from China but nowadays it is cultivated all over the world. The plant contains various flavonoids and terpenes, which are r...
Keywords: Derivatizations, Diseases, Mass spectrometry, Sample preparations, Separation, Size-exclusion chromatography, Thin layer chromatography

Quantification of bitter acids in hops by thin layer chromatography

The amount of bitter acids in hops is a very important parameter for beer production. Different types of hops have different quantities of alpha and beta acids, which are responsible for the bitterne...
Keywords: Chromatography, Mass spectrometry, PAGE, Sample preparations, Spectroscopy, Thin layer chromatography

Sildenafil Citrate USP Method Using HPTLC Plates for the Limit of Imidazole Test

Sildenafil, sold under the brand name Viagra, among others, is a medication that can be used as a selective inhibitor of cyclic GMP- specific photodiesterase (type V) with vasodilator action. It can ...
Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Thin layer chromatography

Solvents for Liquid Chromatography LiChrosolv®

For perfect high-performance liquid chromatography (HPLC) results, high-performance solvents are a must. LiChrosolv® solvents are designed to optimally support analytical HPLC, fast chromatography, a...
Keywords: Chromatography, Evaporation, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Phase transitions, Separation, Solvents

Sucrose Method for IdentificationTest B using silica gel G TLC plates

Sucrose is a common naturally occurring carbohydrate found in many plants and plant parts. The molecule is composed of two monosaccharides; glucose and fructose with the formula C12H22O11.
Dr Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Separation, Thin layer chromatography

Thin Layer Chromatography Identification Test for Etodolac following European Pharmacopeia Monograph on Silica Gel G F 254 Plates

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID). Etodolac is a white crystalline compound, a racemic mixture of [+]S and [-]R-enantiomers insoluble in water but soluble in alcohols, chlorof...
Keywords: Anti-inflammatory agents, Indicators, Thin layer chromatography

Thin Layer Chromatography Identification Test for Folic Acid following European Pharmacopeia Monograph on Silica Gel G F 254 Plates

Folic acid, known as folate in its natural form, is a water soluble compound known as vitamin B9. Folic acid is vital to the body in small amounts, and can found in whole-grain breads, cereals, liver...
Keywords: Solvents, Thin layer chromatography, Vitamins

Thin Layer Chromatography Identification Test for Sucrose following European Pharmacopeia Monograph on Silica Gel G F 254 Plates

Sucrose is a common naturally occurring carbohydrate found in many plants and plant parts. The molecule is  composed of two monosaccharides; glucose and fructose with the formula C12H22O11.
Keywords: Separation, Thin layer chromatography

Thin Layer Chromatography Identification Test for Timolol following European Pharmacopeia Monograph on Silica Gel G F 254 Plates

Timolol is a medication used either by mouth or as eye drops. As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma.
Keywords: Indicators, Thin layer chromatography

USP Dissolution Testing Method (HPLC) for Folic Acid Tablets using a Monolith Column and UV detection

Folic acid or folate is classified as a B vitamin (B9). Folic acid is synthetically produced, and used in fortified foods and supplements. Folate is converted by humans to dihydrofolate (dihydrofolic...
Keywords: Chromatography, High performance liquid chromatography, Sample preparations, Vitamins

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