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1.06323 SAFC

Sodium hydrogen carbonate

EMPROVE® ESSENTIAL Ph Eur,BP,JP,USP,FCC,E 500

Synonym: Sodium bicarbonate

  • CAS Number 144-55-8

  • Linear Formula NaHCO3

  • Molecular Weight 84.01

  •  Beilstein/REAXYS Number 4153970

  •  MDL number MFCD00003528

  •  E Number E500

  •  EC Index Number 205-633-8

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Properties

Agency/Method   BP
  JP
  Ph. Eur.
  USP
Quality Level   500
reg. compliance   FCC
product line   Emprove® Essential
potency   4220 mg/kg LD50, oral (Rat)
pH   8.6 (20 °C, 50 g/L in H2O)
pKa (25 °C)   (1) 6.37, (2) 10.25 (carbonic acid)
mp   270 °C (decomposition)
solubility   96 g/L
density   2.22 g/cm3 at 20 °C
  2.16 g/mL at 25 °C (lit.)
bulk density   1000 kg/m3
SMILES string   [Na+].OC([O-])=O
InChI   1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI key   UIIMBOGNXHQVGW-UHFFFAOYSA-M
storage conditions   Store at +5°C to +30°C.

Description

Application

The specification of the product is part of the Emprove® Material Qualification Dossier and can be found under "General Properties".

Analysis Note

Assay (acidimetric according to Ph Eur): 99.0 - 101.0 %
Assay (acidimetric; calculated on dried substance according to USP): 99.5 - 100.5 %
Assay (acidimetric according to JP): 99.0 - 101.0 %
Identity: passes test
Appearance of solution: passes test
Insoluble matter: passes test
pH-value (1 %, water): 8.0 - 8.6
pH-value (5 %; water): 7.9 - 8.4
Carbonate (CO₃): passes test
Chloride (Cl): ≤ 0.0150 %
Sulfate (SO₄): ≤ 0.01 %
Sulfur compounds (as SO₄): ≤ 0.015 %
Heavy metals (as Pb): ≤ 0.0005 %
Al (Aluminium): ≤ 0.00005 %
As (Arsenic): ≤ 0.0002 %
Ca (Calcium): ≤ 0.0100 %
Cu (Copper): ≤ 0.0005 %
Fe (Iron): ≤ 0.0020 %
Hg (Mercury): ≤ 0.0001 %
NH₄ (Ammonium): ≤ 0.0020 %
NH₄ (Ammonium) according to USP: ≤ 0.0020 %
NH₄ (Ammonium) according to JP: passes test
Pb (Lead): ≤ 0.0002 %
Zn (Zinc): ≤ 0.0025 %
Residual solvents (ICH Q3C): excluded by production process
Loss on drying (Silica gel): ≤ 0.25 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph Eur, BP, USP, FCC, JP, E 500
Conforms to the purity criteria on food additives according to the current European Commission Regulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

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