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1.06514 SAFC

Sodium thiosulfate pentahydrate

cryst., EMPROVE® ESSENTIAL Ph Eur,BP,USP

Synonym: Antichlor, Sodium thiosulfate pentahydrate

  • CAS Number 10102-17-7

  • Empirical Formula (Hill Notation) Na2O3S2 · 5H2O

  • Molecular Weight 248.18

  •  MDL number MFCD00149186

  •  EC Index Number 231-867-5

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Properties

Related Categories APIs (Active Pharmaceutical Ingredients) and Excipients, Antioxidants, Biopharmaceutical Process Development and Manufacturing, Excipients, Liquid Dosage Forms,
Agency/Method   BP
  Ph. Eur.
  USP
Quality Level   500
product line   Emprove® Essential
potency   >5000 mg/kg LD50, oral (Rat)
pH   6.0-7.5 (20 °C, 100 g/L in H2O)
mp   48 °C
density   1.74 g/cm3 at 20 °C
bulk density   1000 kg/m3
InChI   1S/2Na.H2O3S2.5H2O/c;;1-5(2,3)4;;;;;/h;;(H2,1,2,3,4);5*1H2/q2*+1;;;;;;/p-2
InChI key   PODWXQQNRWNDGD-UHFFFAOYSA-L
storage conditions   Store at +15°C to +25°C.

Description

Analysis Note

Assay (iodometric): 99.0 - 101.0 %
Assay (iodometric, calc.on anhydrous substance): 99.0 - 100.5 %
Identity: passes test
Appearance of solution: passes test
pH-value (10 %; water): 6.0 - 8.4
Sulfate and sulphite (as SO₄): ≤ 0.2 %
Sulfide (S): passes test
Heavy metals (as Pb): ≤ 0.001 %
Ca (Calcium): passes test
Residual solvents (ICH Q3C): excluded by manufacturing process
Water: 32.0 - 37.0 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

Corresponds to Ph Eur,BP,USP

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Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

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