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1.08101 Supelco

Tetrahydrofuran

for liquid chromatography LiChrosolv®

Synonym: Butylene oxide, Oxolane, THF, Tetramethylene oxide, Oxolane, Butylene oxide, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  MDL number MFCD00005356

  •  EC Index Number 203-726-8

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Properties

Quality Level   100
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.9% (GC)
form   liquid
autoignition temp.   610 °F
expl. lim.   1.8-11.8 %
application(s)   LC/MS: suitable
refractive index   n20/D 1.407 (lit.)
pH   7-8 (20 °C, 200 g/L in H2O)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
transition temp   flash point -20 °C
density   0.889 g/mL at 25 °C (lit.)
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2
InChI key   WYURNTSHIVDZCO-UHFFFAOYSA-N
storage conditions   Store at +5°C to +30°C.

Description

General description

With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in "gradient grade" as well as "isocratic grade". This enables to minimize the gradient effect of the solvent involved.

Analysis Note

Purity (GC): ≥ 99.9 %
Identity (IR): conforms
Evaporation residue: ≤ 1.0 mg/l
Water: ≤ 0.02 %
Acidity: ≤ 0.0002 meq/g
Alkalinity: ≤ 0.0002 meq/g
Peroxide: ≤ 0.02 %
Transmission (at 218 nm): ≥ 30 %
Transmission (at 230 nm): ≥ 35 %
Transmission (at 250 nm): ≥ 65 %
Transmission (at 280 nm): ≥ 95 %
Filtred by 0.2µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Protocols & Articles

Articles

Alfuzosin USP Monograph – HPLC method for Related Substances

Alfuzosin is an antagonist of the α1 adrenergic receptor and it relaxes the muscles in the prostate and bladder neck, making it easier to urinate. It is used to treat benign prostatic hyperplasia (BP...
Keywords: High performance liquid chromatography

HPLC Analysis of Carbamazepine on Ascentis® Express ES-Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carbamazepine on Ascentis® Express ES-Cyano
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

Lopinavir and Ritonavir Tablets Assay Method Following United States Pharmacopeia Monograph Guidelines Using an Ascentis C8 Column and UV Detection

This application note illustrates how it is possible to set-up an assay method for Lopinavir and Ritonavir tablets. The given experimental conditions follow the current USP43-NF38 monograph; the chro...
Keywords: High performance liquid chromatography

Solvents for Liquid Chromatography LiChrosolv®

For perfect high-performance liquid chromatography (HPLC) results, high-performance solvents are a must. LiChrosolv® solvents are designed to optimally support analytical HPLC, fast chromatography, a...
Keywords: Chromatography, Evaporation, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Phase transitions, Separation, Solvents

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