1.08101 Supelco


for liquid chromatography LiChrosolv®

Synonym: Butylene oxide, Oxolane, THF, Tetramethylene oxide, Oxolane, Butylene oxide, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  MDL number MFCD00005356

  •  EC Index Number 203-726-8



Quality Level   100
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.9% (GC)
form   liquid
autoignition temp.   610 °F
expl. lim.   1.8-11.8 %
application(s)   LC/MS: suitable
refractive index   n20/D 1.407 (lit.)
pH   7-8 (20 °C, 200 g/L in H2O)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
transition temp   flash point -20 °C
density   0.889 g/mL at 25 °C (lit.)
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2
storage conditions   Store at +5°C to +30°C.


General description

With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in "gradient grade" as well as "isocratic grade". This enables to minimize the gradient effect of the solvent involved.

Analysis Note

Purity (GC): ≥ 99.9 %
Identity (IR): conforms
Evaporation residue: ≤ 1.0 mg/l
Water: ≤ 0.02 %
Acidity: ≤ 0.0002 meq/g
Alkalinity: ≤ 0.0002 meq/g
Peroxide: ≤ 0.02 %
Transmission (at 218 nm): ≥ 30 %
Transmission (at 230 nm): ≥ 35 %
Transmission (at 250 nm): ≥ 65 %
Transmission (at 280 nm): ≥ 95 %
Filtred by 0.2µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Protocols & Articles


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Solvents for Liquid Chromatography LiChrosolv®

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